8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carbonyl chloride hydrochloride

Base Information

Chemical Name:8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carbonyl chloride hydrochloride
CAS No.:1415502-89-4
Molecular Formula:C₁₆H₁₁ClF₂N₂O₂*ClH
Molecular Weight:373.186
Hs Code.:

Synonyms:8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carbonyl chloride hydrochloride

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Chemical Property of 8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carbonyl chloride hydrochloride

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Technology Process of 8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carbonyl chloride hydrochloride

There total 3 articles about 8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carbonyl chloride hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1415501-19-7
8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a] pyridine-3-carboxylic acid

: 1415502-89-4
8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carbonyl chloride hydrochloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 7h;

Reference yield:

: 85118-00-9
2,6-Difluorobenzyl bromide

: 1415502-89-4
8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carbonyl chloride hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 0.25 h / 20 °C

1.2: 4 h / 20 °C

2.1: ethanol / 24 h / Molecular sieve; Reflux

3.1: lithium hydroxide; water / methanol; tetrahydrofuran / 16 h / 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 7 h / 20 °C

With oxalyl dichloride; water; sodium methylate; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; methanol; ethanol;

Reference yield:

: 16867-03-1
2-amino-3-hydroxypyridine

: 1415502-89-4
8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carbonyl chloride hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 0.25 h / 20 °C

1.2: 4 h / 20 °C

2.1: ethanol / 24 h / Molecular sieve; Reflux

3.1: lithium hydroxide; water / methanol; tetrahydrofuran / 16 h / 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 7 h / 20 °C

With oxalyl dichloride; water; sodium methylate; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; methanol; ethanol;