carbonic acid 2-[3-bromo-1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxy-phenyl ester ethyl ester

Base Information

• Chemical Name: carbonic acid 2-[3-bromo-1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxy-phenyl ester ethyl ester
• CAS No.: 519753-23-2
• Molecular Formula: C₃₃H₃₄BrNO₉
• Molecular Weight: 668.538
• Mol file: 519753-23-2.mol

Synonyms:carbonic acid 2-[3-bromo-1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxy-phenyl ester ethyl ester

Chemical Property of carbonic acid 2-[3-bromo-1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxy-phenyl ester ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of carbonic acid 2-[3-bromo-1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxy-phenyl ester ethyl ester

There total 5 articles about carbonic acid 2-[3-bromo-1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxy-phenyl ester ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-[1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxyphenyl ethyl carbonate (519753-21-0) → carbonic acid 2-[3-bromo-1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxy-phenyl ester ethyl ester (519753-23-2)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 20 ℃;

DOI:10.1016/S0040-4039(02)02887-3

Reference yield:

2-hydroxy-4,5-dimethoxyacetophenone (20628-06-2) → carbonic acid 2-[3-bromo-1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxy-phenyl ester ethyl ester (519753-23-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 83 percent / NaH / tetrahydrofuran / 20 °C

2: 90 percent / BnMe₃NBr₃ / CH₂Cl₂ / 0 - 20 °C

3: NaHCO₃ / acetonitrile / Heating

4: 95 percent / NBS / CH₂Cl₂ / 20 °C

With N-Bromosuccinimide; sodium hydride; sodium hydrogencarbonate; benzyltrimethylazanium tribroman-2-uide; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(02)02887-3

Reference yield:

3,4-dimethoxyphenol (2033-89-8) → carbonic acid 2-[3-bromo-1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxy-phenyl ester ethyl ester (519753-23-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / BF₃*Et₂O / 80 - 90 °C

2: 83 percent / NaH / tetrahydrofuran / 20 °C

3: 90 percent / BnMe₃NBr₃ / CH₂Cl₂ / 0 - 20 °C

4: NaHCO₃ / acetonitrile / Heating

5: 95 percent / NBS / CH₂Cl₂ / 20 °C

With N-Bromosuccinimide; boron trifluoride diethyl etherate; sodium hydride; sodium hydrogencarbonate; benzyltrimethylazanium tribroman-2-uide; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(02)02887-3

upstream raw materials:

2-[1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxyphenyl ethyl carbonate

2-hydroxy-4,5-dimethoxyacetophenone

3,4-dimethoxyphenol

carbonic acid 2-acetyl-4,5-dimethoxy-phenyl ester ethyl ester