2-[1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxyphenyl ethyl carbonate

Base Information

• Chemical Name: 2-[1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxyphenyl ethyl carbonate
• CAS No.: 519753-21-0
• Molecular Formula: C₃₃H₃₅NO₉
• Molecular Weight: 589.642
• Mol file: 519753-21-0.mol

Synonyms:2-[1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxyphenyl ethyl carbonate

Chemical Property of 2-[1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxyphenyl ethyl carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxyphenyl ethyl carbonate

There total 6 articles about 2-[1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxyphenyl ethyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

chloroformic acid ethyl ester (541-41-3) + 2-[1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxy-phenol → 2-[1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxyphenyl ethyl carbonate (519753-21-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4039(02)02887-3

Reference yield:

carbonic acid 2-acetyl-4,5-dimethoxy-phenyl ester ethyl ester (519753-19-6) → 2-[1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxyphenyl ethyl carbonate (519753-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: polymer bound pyridine hydrobromide perbromide / CH₂Cl₂ / 18 h / 0 - 20 °C

2: Amberlyst A-26 NaCO₃^(1-) / acetonitrile / 20 h / Heating

With Amberlyst A-26 NaCO₃^(1-); polymer bound pyridine hydrobromide perbromide; In dichloromethane; acetonitrile;

DOI:10.1021/jo050388m

Reference yield:

3,4-dihydropapaverine (6957-27-3) + 2-(2-bromoacetyl)-4,5-dimethoxyphenyl ethyl carbonate (519753-18-5) → 2-[1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxyphenyl ethyl carbonate (519753-21-0)

Guidance literature:

With Amberlyst A-26 NaCO₃^(1-); In acetonitrile; for 20h; Heating;

DOI:10.1021/jo050388m

upstream raw materials:

chloroformic acid ethyl ester

1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3.4-dihydroisoquinoline hydrochloride

2-(2-bromoacetyl)-4,5-dimethoxyphenyl ethyl carbonate

3,4-dihydropapaverine

Downstream raw materials:

14-(3,4-dimethoxyphenyl)-2,3,11,12-tetramethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

carbonic acid 2-[3-bromo-1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-4,5-dimethoxy-phenyl ester ethyl ester