ethyl 2-(4-((4-(4-nitrophenylsulfonamido)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetate

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Chemical Name:ethyl 2-(4-((4-(4-nitrophenylsulfonamido)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetate
CAS No.:1404435-39-7
Molecular Formula:C₂₁H₁₉N₇O₆S
Molecular Weight:497.491
Hs Code.:

Synonyms:ethyl 2-(4-((4-(4-nitrophenylsulfonamido)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetate

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Chemical Property of ethyl 2-(4-((4-(4-nitrophenylsulfonamido)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetate

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Technology Process of ethyl 2-(4-((4-(4-nitrophenylsulfonamido)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetate

There total 4 articles about ethyl 2-(4-((4-(4-nitrophenylsulfonamido)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1404232-82-1
ethyl 2-(4-((4-aminophenyl) amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetate

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1404435-39-7
ethyl 2-(4-((4-(4-nitrophenylsulfonamido)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetate

Guidance literature:: ethyl 2-(4-((4-aminophenyl) amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

4-Nitrobenzenesulfonyl chloride; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1016/j.ejmech.2013.05.019

Reference yield:

: 5399-92-8
4-chloro-1H-pyrazolo[3,4-d]pyrimidine

: 1404435-39-7
ethyl 2-(4-((4-(4-nitrophenylsulfonamido)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: acetonitrile / 3 h / 80 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

3.2: 2 h / 0 °C

With sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2013.05.019

Reference yield:

: 1343261-36-8
ethyl 2-(4-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetate

: 1404435-39-7
ethyl 2-(4-((4-(4-nitrophenylsulfonamido)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetonitrile / 3 h / 80 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 2 h / 0 °C

With sodium hydride; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.ejmech.2013.05.019