3-[2[[(1,1-Dimethylethyl)dimethyl silyl]oxy]ethyl]-piperidine

Base Information

• Chemical Name: 3-[2[[(1,1-Dimethylethyl)dimethyl silyl]oxy]ethyl]-piperidine
• CAS No.: 146667-82-5
• Molecular Formula: C₁₃H₂₉NOSi
• Molecular Weight: 243.465
• DSSTox Substance ID: DTXSID80434581
• Mol file: 146667-82-5.mol

Synonyms:146667-82-5;3-[2[[(1,1-Dimethylethyl)dimethyl silyl]oxy]ethyl]-piperidine;Tert-butyl-dimethyl-(2-piperidin-3-ylethoxy)silane;SCHEMBL5214196;DTXSID80434581;XBHDWFMJLMOWCM-UHFFFAOYSA-N;AKOS015961637;AC-14494;3-(2-(tert-butyldimethylsilyloxy)ethyl)piperidine;3-(2-{[tert-Butyl(dimethyl)silyl]oxy}ethyl)piperidine;Propanoic acid, 2,2-dimethyl-, 1,1-diethylpropyl ester;(+/-)-3-[2-(tert-butyldimethylsilyloxy)ethyl]piperidine

Chemical Property of 3-[2[[(1,1-Dimethylethyl)dimethyl silyl]oxy]ethyl]-piperidine

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.439
• Boiling Point: 274.253°C at 760 mmHg
• Flash Point: 119.664°C
• PSA: 21.26000
• Density: 0.866g/cm³
• LogP: 3.72670
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 243.201841083
• Heavy Atom Count: 16
• Complexity: 211

Purity/Quality:

3-[2[[(1,1-DIMETHYLETHYL)DIMETHYL SILYL]OXY]ETHYL]-PIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C)[Si](C)(C)OCCC1CCCNC1

Technology Process of 3-[2[[(1,1-Dimethylethyl)dimethyl silyl]oxy]ethyl]-piperidine

There total 4 articles about 3-[2[[(1,1-Dimethylethyl)dimethyl silyl]oxy]ethyl]-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-(2-ethyl)pyridine (146667-81-4) → 3-(2-ethyl)piperidine (146667-82-5)

Guidance literature:

With platinum(IV) oxide; hydrogen; acetic acid; In ethanol; water; for 20h; under 2068.6 Torr;

Reference yield:

3-pyridinylethanol (6293-56-7) → 3-(2-ethyl)piperidine (146667-82-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / triethylamine / CH₂Cl₂ / 5 h / Ambient temperature

2: 99 percent / glacial acetic acid, platinum oxide hydrate, hydrogen / ethanol; H₂O / 20 h / 2068.6 Torr

With platinum(IV) oxide; hydrogen; acetic acid; triethylamine; In ethanol; dichloromethane; water;

Reference yield:

pyridin-3-yl-acetic acid ethyl ester (39931-77-6) → 3-(2-ethyl)piperidine (146667-82-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / lithium aluminum hydride / diethyl ether; tetrahydrofuran / 2 h

2: 87 percent / triethylamine / CH₂Cl₂ / 5 h / Ambient temperature

3: 99 percent / glacial acetic acid, platinum oxide hydrate, hydrogen / ethanol; H₂O / 20 h / 2068.6 Torr

With platinum(IV) oxide; lithium aluminium tetrahydride; hydrogen; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;

upstream raw materials:

3-(2-ethyl)pyridine

3-pyridinylethanol

pyridin-3-yl-acetic acid ethyl ester

tert-butyldimethylsilyl chloride

Downstream raw materials:

tert-butyl 3-vinyl-1-piperidynecarboxylate

tert-butyl 3-(2-hydroxyethyl)-1-piperidinecarboxylate

tert-butyl 3-(2-<4-tolylsulfonyloxy>ethyl)-1-piperidinecarboxylate