N-(4-{(1R,4S)-4-[3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)ureido]-1,2,3,4-tetrahydronaphthalen-1-yloxymethyl}pyridin-2-yl)-2-methoxyacetamide

Base Information

Chemical Name:N-(4-{(1R,4S)-4-[3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)ureido]-1,2,3,4-tetrahydronaphthalen-1-yloxymethyl}pyridin-2-yl)-2-methoxyacetamide
CAS No.:1443251-66-8
Molecular Formula:C₃₄H₄₀N₆O₄
Molecular Weight:596.729
Hs Code.:

Synonyms:N-(4-{(1R,4S)-4-[3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)ureido]-1,2,3,4-tetrahydronaphthalen-1-yloxymethyl}pyridin-2-yl)-2-methoxyacetamide

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Chemical Property of N-(4-{(1R,4S)-4-[3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)ureido]-1,2,3,4-tetrahydronaphthalen-1-yloxymethyl}pyridin-2-yl)-2-methoxyacetamide

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Technology Process of N-(4-{(1R,4S)-4-[3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)ureido]-1,2,3,4-tetrahydronaphthalen-1-yloxymethyl}pyridin-2-yl)-2-methoxyacetamide

There total 9 articles about N-(4-{(1R,4S)-4-[3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)ureido]-1,2,3,4-tetrahydronaphthalen-1-yloxymethyl}pyridin-2-yl)-2-methoxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 317806-87-4
2,2,2-trichloroethyl 3-tert-butyl-1-p-tolyl-1H-pyrazol-5-ylcarbamate

: 1443252-58-1
N-(4-((((1R,4S)-4-amino-1,2,3,4-tetrahydronaphthalen-1-yl)oxy)methyl)pyridin-2-yl)-2-methoxyacetamide

: 1443251-66-8
N-(4-{(1R,4S)-4-[3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)ureido]-1,2,3,4-tetrahydronaphthalen-1-yloxymethyl}pyridin-2-yl)-2-methoxyacetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 80 ℃; for 16h; Inert atmosphere;

Reference yield:

: 2,2,2-trifluoro-N-[(S)-1,2,3,4-tetrahydronaphthalene-1-yl]acetamide

: 1443251-66-8
N-(4-{(1R,4S)-4-[3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)ureido]-1,2,3,4-tetrahydronaphthalen-1-yloxymethyl}pyridin-2-yl)-2-methoxyacetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium permanganate; magnesium sulfate monohydrate / acetone / 18.75 h / Cooling with ice

2.1: triethylamine; Noyori's catalyst; formic acid / N,N-dimethyl-formamide / 18 h / 60 °C / Inert atmosphere; Cooling with ice

3.1: sodium hydroxide; water / methanol / 3.5 h / Cooling with ice

4.1: acetonitrile / 22 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Inert atmosphere; Cooling with ice

5.2: 1 h / Cooling with ice; Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / Cooling with ice

7.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

With potassium permanganate; formic acid; Noyori's catalyst; magnesium sulfate monohydrate; water; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile; mineral oil;

Reference yield:

: 1443252-55-8
((1S,4R)-4-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)carbamic acid tert-butyl ester

: 1443251-66-8
N-(4-{(1R,4S)-4-[3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)ureido]-1,2,3,4-tetrahydronaphthalen-1-yloxymethyl}pyridin-2-yl)-2-methoxyacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Inert atmosphere; Cooling with ice

1.2: 1 h / Cooling with ice; Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / Cooling with ice

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

With sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil;