Aminoxy-PEG3-azide

Base Information

Chemical Name:Aminoxy-PEG3-azide
CAS No.:1306615-51-9
Molecular Formula:C₈H₁₈N₄O₄
Molecular Weight:234.255
Hs Code.:

Synonyms:O-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)hydroxylamine

Suppliers and Price of Aminoxy-PEG3-azide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Aminoxy-PEG3-Azide
50mg
$ 695.00

BroadPharm
Aminooxy-PEG3-azide 95%
250 MG
$ 650.00

Total 12 raw suppliers

Chemical Property of Aminoxy-PEG3-azide

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Aminoxy-PEG3-Azide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Aminooxy-PEG3-azide is a crosslinker containing an aminooxy group and an azide group.The azide group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.
Uses Aminoxy-PEG3-Azide is a useful compound in the synthesis of tryptophan-folate conjugates. Polypeptide including a morpholino linker.

Technology Process of Aminoxy-PEG3-azide

There total 4 articles about Aminoxy-PEG3-azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1235514-15-4
tert-butyl 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxycarbamate

: 1306615-51-9
O-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)hydroxylamine

Guidance literature:: With water; trifluoroacetic acid; at 20 ℃; for 1.5h;
DOI:10.1002/anie.201108130

Reference yield: 93.0%

: 1379799-43-5
2-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)isoindoline-1,3-dione

: 1306615-51-9
O-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)hydroxylamine

Guidance literature:: With ammonia; In methanol; at 40 ℃;
DOI:10.1021/ja303904e

Reference yield:

: 86770-67-4
2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol

: 1306615-51-9
O-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)hydroxylamine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 4 - 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / diethyl ether / 4 - 20 °C

3: water; trifluoroacetic acid / 1.5 h / 20 °C

With water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; In diethyl ether; dichloromethane;
DOI:10.1002/anie.201108130