N-(2-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)phenyl)acrylamide trifluoroacetate

Base Information

Chemical Name:N-(2-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)phenyl)acrylamide trifluoroacetate
CAS No.:1431959-37-3
Molecular Formula:C₂HF₃O₂*C₂₀H₂₁N₅OS
Molecular Weight:493.51
Hs Code.:

Synonyms:N-(2-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)phenyl)acrylamide trifluoroacetate

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Chemical Property of N-(2-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)phenyl)acrylamide trifluoroacetate

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Technology Process of N-(2-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)phenyl)acrylamide trifluoroacetate

There total 3 articles about N-(2-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)phenyl)acrylamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431960-62-1
C₁₇H₁₉N₅S

: 814-68-6,25189-84-8
acryloyl chloride

: 76-05-1
trifluoroacetic acid

: 1431959-37-3
N-(2-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)phenyl)acrylamide trifluoroacetate

Guidance literature:: C₁₇H₁₉N₅S; acryloyl chloride; With triethylamine; at 0 ℃; for 1h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 888498-07-5
(1H-pyrrolo[2,3-b]pyridin-4-yl)methanamine

: 1431959-37-3
N-(2-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)phenyl)acrylamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; dmap / methanol / 0.5 h / 20 °C / Cooling with ice

1.2: 1.58 h / 20 °C / Cooling with ice

2.1: triethylamine / dichloromethane / 5 h

3.1: triethylamine / 1 h / 0 °C

With dmap; triethylamine; In methanol; dichloromethane;

Reference yield:

: 1431959-92-0
C₉H₇N₃S

: 1431959-37-3
N-(2-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)phenyl)acrylamide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 5 h

2: triethylamine / 1 h / 0 °C

With triethylamine; In dichloromethane;