erythro-2-<1-hydroxy(phenyl)methyl>-1-isopropoxy-1-methylsilacyclopentane

Base Information

Chemical Name:erythro-2-<1-hydroxy(phenyl)methyl>-1-isopropoxy-1-methylsilacyclopentane
CAS No.:137472-45-8
Molecular Formula:C₁₅H₂₄O₂Si
Molecular Weight:264.44
Hs Code.:

Synonyms:erythro-2-<1-hydroxy(phenyl)methyl>-1-isopropoxy-1-methylsilacyclopentane

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Chemical Property of erythro-2-<1-hydroxy(phenyl)methyl>-1-isopropoxy-1-methylsilacyclopentane

Chemical Property:

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Technology Process of erythro-2-<1-hydroxy(phenyl)methyl>-1-isopropoxy-1-methylsilacyclopentane

There total 6 articles about erythro-2-<1-hydroxy(phenyl)methyl>-1-isopropoxy-1-methylsilacyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 2388-10-5
lithium isopropoxide

: 137472-39-0,137472-40-3
1-<(Z)-1,2-epoxy-2-phenylethyl>-1-methylsilacyclobutane

: 137472-45-8
erythro-2-<1-hydroxy(phenyl)methyl>-1-isopropoxy-1-methylsilacyclopentane

Guidance literature:: at -78 ℃;
DOI:10.1016/0040-4039(91)80035-5

Reference yield:

: 162754-70-3
1-methyl-1-(phenylethynyl)silacyclobutane

: 137472-45-8
erythro-2-<1-hydroxy(phenyl)methyl>-1-isopropoxy-1-methylsilacyclopentane

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / diisobutylaluminium hydride / hexane; diethyl ether / 1.) 0 deg C, 2 h, 2.) RT, 8 h

2: 59 percent / m-CPBA / CHCl₃ / 1.) 0 deg C, 5 min, 2.) RT, 1 h

3: 1.) BuLi / 1.) hexane, THF, 30 min, 2.) THF, -78 deg C, 30 min

With n-butyllithium; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; hexane; chloroform;
DOI:10.1246/bcsj.68.250

Reference yield:

: 536-74-3
phenylacetylene

: 137472-45-8
erythro-2-<1-hydroxy(phenyl)methyl>-1-isopropoxy-1-methylsilacyclopentane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) THF, 0 deg C, 30 min

2: 72 percent / diisobutylaluminium hydride / hexane; diethyl ether / 1.) 0 deg C, 2 h, 2.) RT, 8 h

3: 59 percent / m-CPBA / CHCl₃ / 1.) 0 deg C, 5 min, 2.) RT, 1 h

4: 1.) BuLi / 1.) hexane, THF, 30 min, 2.) THF, -78 deg C, 30 min

With n-butyllithium; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; hexane; chloroform;
DOI:10.1246/bcsj.68.250