(2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)[6-(trifluoromethyl)pyridin-3-yl]methanol trifluoroacetate

Base Information

Chemical Name:(2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)[6-(trifluoromethyl)pyridin-3-yl]methanol trifluoroacetate
CAS No.:1600565-31-8
Molecular Formula:C₂HF₃O₂*C₂₆H₁₇Cl₂F₃N₄O
Molecular Weight:643.372
Hs Code.:

Synonyms:(2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)[6-(trifluoromethyl)pyridin-3-yl]methanol trifluoroacetate

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Chemical Property of (2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)[6-(trifluoromethyl)pyridin-3-yl]methanol trifluoroacetate

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Technology Process of (2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)[6-(trifluoromethyl)pyridin-3-yl]methanol trifluoroacetate

There total 9 articles about (2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)[6-(trifluoromethyl)pyridin-3-yl]methanol trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1599524-55-6
(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanone

: 1600562-81-9
6-bromo-2,4-dichloro-3-phenylquinoline

: 76-05-1
trifluoroacetic acid

: 1600565-31-8
(2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)[6-(trifluoromethyl)pyridin-3-yl]methanol trifluoroacetate

Guidance literature:: (1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanone; 6-bromo-2,4-dichloro-3-phenylquinoline; In tetrahydrofuran; at -78 ℃; Inert atmosphere; Cooling with acetone-dry ice;

With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 2.5h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 358780-13-9
6-(trifluoromethyl)nicotinoyl chloride

: 1600565-31-8
(2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)[6-(trifluoromethyl)pyridin-3-yl]methanol trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 7 - 20 °C

2.1: TurboGrignard / tetrahydrofuran / 1 h / 16.6 - 25 °C

2.2: 2 h / 20 °C

3.1: tetrahydrofuran / -78 °C / Inert atmosphere; Cooling with acetone-dry ice

3.2: 2.5 h / -78 °C

With TurboGrignard; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 452349-62-1
methyl 5-bromo-2-(2-phenylacetamido)benzoate

: 1600565-31-8
(2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)[6-(trifluoromethyl)pyridin-3-yl]methanol trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 4 h / -78 - 20 °C

2.1: trichlorophosphate / 3.5 h / 107 °C

3.1: tetrahydrofuran / -78 °C / Inert atmosphere; Cooling with acetone-dry ice

3.2: 2.5 h / -78 °C

With lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; hexane;