2-[4-(ethylsulfonyl)phenyl]-N-{4-[({[4-(trifluoromethyl)phenyl]methyl}amino)methyl]phenyl}acetamide

Base Information

Chemical Name:2-[4-(ethylsulfonyl)phenyl]-N-{4-[({[4-(trifluoromethyl)phenyl]methyl}amino)methyl]phenyl}acetamide
CAS No.:1508310-41-5
Molecular Formula:C₂₅H₂₅F₃N₂O₃S
Molecular Weight:490.546
Hs Code.:

Synonyms:2-[4-(ethylsulfonyl)phenyl]-N-{4-[({[4-(trifluoromethyl)phenyl]methyl}amino)methyl]phenyl}acetamide

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Chemical Property of 2-[4-(ethylsulfonyl)phenyl]-N-{4-[({[4-(trifluoromethyl)phenyl]methyl}amino)methyl]phenyl}acetamide

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Technology Process of 2-[4-(ethylsulfonyl)phenyl]-N-{4-[({[4-(trifluoromethyl)phenyl]methyl}amino)methyl]phenyl}acetamide

There total 4 articles about 2-[4-(ethylsulfonyl)phenyl]-N-{4-[({[4-(trifluoromethyl)phenyl]methyl}amino)methyl]phenyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.9%

: 3300-51-4
p-Trifluoromethylbenzylamine

: 1508310-55-1
2-[4-(ethylsulfonyl)phenyl]-N-(4-formylphenyl)acetamide

: 1508310-41-5
2-[4-(ethylsulfonyl)phenyl]-N-{4-[({[4-(trifluoromethyl)phenyl]methyl}amino)methyl]phenyl}acetamide

Guidance literature:: p-Trifluoromethylbenzylamine; 2-[4-(ethylsulfonyl)phenyl]-N-(4-formylphenyl)acetamide; In tetrahydrofuran; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1021/ml4003875

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 1508310-41-5
2-[4-(ethylsulfonyl)phenyl]-N-{4-[({[4-(trifluoromethyl)phenyl]methyl}amino)methyl]phenyl}acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 2 h / 143 °C / Dean-Stark

2.1: hydrogen / methanol; tetrahydrofuran / 4.5 h / 35 °C / 30003 Torr

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

3.2: 2 h / 20 °C

4.1: tetrahydrofuran / 1 h / 20 °C

4.2: 24 h / 20 °C

With hydrogen; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/ml4003875

Reference yield:

: 2403-53-4
2-(4-nitrophenyl)-1,3-dioxolane

: 1508310-41-5
2-[4-(ethylsulfonyl)phenyl]-N-{4-[({[4-(trifluoromethyl)phenyl]methyl}amino)methyl]phenyl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / methanol; tetrahydrofuran / 4.5 h / 35 °C / 30003 Torr

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

2.2: 2 h / 20 °C

3.1: tetrahydrofuran / 1 h / 20 °C

3.2: 24 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ml4003875