2-(3-{3-[(E)-2-(7-chloroquinolin-2yl)vinyl]phenyl}-3-methylaminopropyl)-N,N-diethylbenzamide

Base Information

Chemical Name:2-(3-{3-[(E)-2-(7-chloroquinolin-2yl)vinyl]phenyl}-3-methylaminopropyl)-N,N-diethylbenzamide
CAS No.:1429879-06-0
Molecular Formula:C₃₂H₃₄ClN₃O
Molecular Weight:512.094
Hs Code.:

Synonyms:2-(3-{3-[(E)-2-(7-chloroquinolin-2yl)vinyl]phenyl}-3-methylaminopropyl)-N,N-diethylbenzamide

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Chemical Property of 2-(3-{3-[(E)-2-(7-chloroquinolin-2yl)vinyl]phenyl}-3-methylaminopropyl)-N,N-diethylbenzamide

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Technology Process of 2-(3-{3-[(E)-2-(7-chloroquinolin-2yl)vinyl]phenyl}-3-methylaminopropyl)-N,N-diethylbenzamide

There total 7 articles about 2-(3-{3-[(E)-2-(7-chloroquinolin-2yl)vinyl]phenyl}-3-methylaminopropyl)-N,N-diethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

: 1429879-05-9
[1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-(2-diethylcarbamoylphenyl)propyl]methylcarbamic acid tert-butyl ester

: 1429879-06-0
2-(3-{3-[(E)-2-(7-chloroquinolin-2yl)vinyl]phenyl}-3-methylaminopropyl)-N,N-diethylbenzamide

Guidance literature:: With sulfuric acid; In dichloromethane; for 1h;

Reference yield:

: 1429874-30-5
2-(3-tert-butoxycarbonylamino-3-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}propyl)benzoic acid

: 1429879-06-0
2-(3-{3-[(E)-2-(7-chloroquinolin-2yl)vinyl]phenyl}-3-methylaminopropyl)-N,N-diethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; pivaloyl chloride / acetonitrile / 0.5 h

1.2: 3 h

2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 60 °C

3.1: sulfuric acid / dichloromethane / 1 h

With sulfuric acid; pivaloyl chloride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 149968-11-6
methyl 2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate

: 1429879-06-0
2-(3-{3-[(E)-2-(7-chloroquinolin-2yl)vinyl]phenyl}-3-methylaminopropyl)-N,N-diethylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate; methanol / dichloromethane / 1 h / Inert atmosphere

2.1: acetic acid; sulfuric acid / water / 24 h / 0 - 20 °C

3.1: hydrogenchloride; water / 1,4-dioxane / 110 °C

4.1: triethylamine / water; acetonitrile / 0.5 h

5.1: triethylamine; pivaloyl chloride / acetonitrile / 0.5 h

5.2: 3 h

6.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 60 °C

7.1: sulfuric acid / dichloromethane / 1 h

With hydrogenchloride; methanol; sodium tetrahydroborate; sulfuric acid; water; pivaloyl chloride; sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;