N-<azetidin-2-yl>carbonyl>glycine benzyl ester

Base Information

Chemical Name:N-<azetidin-2-yl>carbonyl>glycine benzyl ester
CAS No.:127310-67-2
Molecular Formula:C₂₈H₂₈N₂O₅
Molecular Weight:472.541
Hs Code.:

N-<<cis-1-benzyl-4-<(benzyloxy)carbonyl>azetidin-2-yl>carbonyl>glycine benzyl ester

Synonyms:N-<azetidin-2-yl>carbonyl>glycine benzyl ester

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Chemical Property of N-<azetidin-2-yl>carbonyl>glycine benzyl ester

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Technology Process of N-<azetidin-2-yl>carbonyl>glycine benzyl ester

There total 11 articles about N-<azetidin-2-yl>carbonyl>glycine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1738-76-7
glycine benzyl ester p-toluenesulfonic acid salt

: (2R,4S)-1-Benzyl-4-isobutoxycarbonyloxycarbonyl-azetidine-2-carboxylic acid benzyl ester

: 127310-67-2
N-<azetidin-2-yl>carbonyl>glycine benzyl ester

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide; at -20 ℃; for 0.166667h; Yield given;
DOI:10.1021/jm00168a007

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 127310-67-2
N-<azetidin-2-yl>carbonyl>glycine benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / TsOH*H₂O / benzene / 8 h / Heating

2: 34 percent / dimethylformamide / 80 °C

3: CH₂Cl₂; toluene / 0 °C

4: 26 percent / triethylamine, cuprous bromide/dimethyl sulfide complex / tetrahydrofuran / 2 h / Ambient temperature

With dimethylsulfide; toluene-4-sulfonic acid; triethylamine; copper(I) bromide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jm00168a007

Reference yield:

: 100-46-9
benzylamine

: 127310-67-2
N-<azetidin-2-yl>carbonyl>glycine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 34 percent / dimethylformamide / 80 °C

2: CH₂Cl₂; toluene / 0 °C

3: 26 percent / triethylamine, cuprous bromide/dimethyl sulfide complex / tetrahydrofuran / 2 h / Ambient temperature

With dimethylsulfide; triethylamine; copper(I) bromide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00168a007