N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzenesulfonamide

Base Information

Chemical Name:N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzenesulfonamide
CAS No.:1342890-68-9
Molecular Formula:C₂₅H₂₆N₂O₅S
Molecular Weight:466.558
Hs Code.:

Synonyms:N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzenesulfonamide

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Chemical Property of N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzenesulfonamide

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Technology Process of N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzenesulfonamide

There total 5 articles about N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1342891-17-1
N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)aniline

: 23095-31-0
3,4-dimethoxybenzene-1-sulfonyl chloride

: 1342890-68-9
N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; for 24h;

Reference yield:

: 115-19-5
2-methyl-but-3-yn-2-ol

: 1342890-68-9
N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic anhydride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 0 °C

1.2: 0.5 h

2.1: xylene / 0.5 h / 130 °C / Microwave irradiation

3.1: n-butyllithium / tetrahydrofuran / 0.58 h / -78 °C

3.2: 0.5 h / -78 °C

4.1: zinc(II) chloride / methanol / 2 h / 20 °C

5.1: triethylamine / dichloromethane / 24 h

With n-butyllithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic anhydride; zinc(II) chloride; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; xylene;

Reference yield:

: 1342891-40-0
2-bromo-5-((2-methylbut-3-yn-2-yl)oxy)pyridine

: 1342890-68-9
N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: xylene / 0.5 h / 130 °C / Microwave irradiation

2.1: n-butyllithium / tetrahydrofuran / 0.58 h / -78 °C

2.2: 0.5 h / -78 °C

3.1: zinc(II) chloride / methanol / 2 h / 20 °C

4.1: triethylamine / dichloromethane / 24 h

With n-butyllithium; triethylamine; zinc(II) chloride; In tetrahydrofuran; methanol; dichloromethane; xylene;