N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Base Information

Chemical Name:N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
CAS No.:1195778-89-2
Molecular Formula:C₂₈H₂₃F₂N₅O₄
Molecular Weight:531.519
Hs Code.:

Synonyms:N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

There total 9 articles about N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 849217-48-7
((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid

: 1195781-35-1
N-[6-(4-amino-3-fluorophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

: 1195778-89-2
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In ISOPROPYLAMIDE; at 20 ℃; for 20h;

Reference yield:

: 1195781-27-1
benzyl {4-[(6-aminopyridin-3-yl)oxy]-2-fluorophenyl}carbamate

: 1195778-89-2
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 3 h / 80 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: trifluoroacetic anhydride / tetrahydrofuran / 3 h / 20 °C

3.3: 4 h / 20 °C

4.1: ISOPROPYLAMIDE / 0 - 20 °C

5.1: water; barium(II) hydroxide / 1,2-dimethoxyethane / 16 h / 90 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / ISOPROPYLAMIDE / 20 h / 20 °C

With pyridine; water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic anhydride; barium(II) hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;

Reference yield:

: 399-95-1
4-amino-3-fluorophenol

: 1195778-89-2
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C

2.1: caesium carbonate / dimethyl sulfoxide / 6 h / 20 °C

3.1: water; iron; calcium chloride / ethanol / 8 h / Reflux

4.1: pyridine / 3 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

6.1: trifluoroacetic anhydride / tetrahydrofuran / 3 h / 20 °C

6.3: 4 h / 20 °C

7.1: ISOPROPYLAMIDE / 0 - 20 °C

8.1: water; barium(II) hydroxide / 1,2-dimethoxyethane / 16 h / 90 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / ISOPROPYLAMIDE / 20 h / 20 °C

With pyridine; water; iron; sodium hydrogencarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic anhydride; calcium chloride; barium(II) hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; ISOPROPYLAMIDE; water; dimethyl sulfoxide; N,N-dimethyl-formamide;