849217-48-7

Basic information

• Product Name: 1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID
• Synonyms: 1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;Cyclopropanecarboxylic acid, 1-[[(4-fluorophenyl)aMino]carbonyl]-;1-{[(4-fluorophenyl)aMino]carbonyl}cyclopropanecarboxylic acid;InterMediate of Cabozantinib;FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;((4-fluorophenyl)carbamoyl)cyclopropane carboxylic acid;1-(5-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;Intermediate2 of Cabozantinib
• CAS NO: 849217-48-7
• Molecular Formula: C₁₁H₁₀FNO₃
• Molecular Weight: 223.21
• EINECS: 1592732-453-0
• Mol File: 849217-48-7.mol
• Article Data: 57

Chemical Properties

• Melting Point: 173.0 to 177.0 °C
• Boiling Point: 475.2oC at 760 mmHg
• Flash Point: 241.2oC
• Appearance: /
• Density: 1.521
• Vapor Pressure: 7.78E-10mmHg at 25°C
• Refractive Index: 1.651
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 3.48±0.20(Predicted)
• CAS DataBase Reference: 1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID(849217-48-7)
• EPA Substance Registry System: 1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID(849217-48-7)

Safety Data

• Hazardous Substances Data: 849217-48-7(Hazardous Substances Data)

Usage

Chemical Properties

White powdery substance.

Uses

1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid is a useful research chemical that can be used as a cabozantinib intermediate.

InChI:InChI=1/C11H10FNO3/c12-7-1-3-8(4-2-7)13-9(14)11(5-6-11)10(15)16/h1-4H,5-6H2,(H,13,14)(H,15,16)

Upstream product

• 6914-71-2 dimethyl 1,1-cyclopropanedicarboxylate 
• 34782-60-0 cyclopropane-1,1-dicarboxylic acid dichloride 
• 371-40-4 4-fluoroaniline 
• 3697-66-3 1,1-cyclopropanedicarboxylic acid monoethyl ester 
• 598-10-7 cyclopropane-1,1-dicarboxylic acid 
• 40258-99-9 1-(chlorocarbonyl)cyclopropane-1-carboxylic acid 
• 1345847-71-3 methyl 1-((4-fluorophenyl)amidomethyl)cyclopropyl-1-carboxylate 
• 113020-21-6 1,1-cyclopropanedicarboxylic acid monomethyl ester 
• 1245931-90-1 ethyl 1-(4-fluorophenylcarbamoyl)cyclopropanecarboxylate 
• 372-19-0 meta-fluoroaniline 
• 1174171-88-0 C₇H₉O₄^(1-)*Na⁽¹⁺⁾ 
• 1559-02-0 diethyl cyclopropane-1,1-dicarboxylate 

Downstream Products

• 928038-31-7 N-{4-[(2-Aminopyridin-4-yl)oxy]-2-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 928038-40-8 N-(4-{[2-Aminopyridin-4-yl)oxy]-2,5-difluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1345848-28-3 (S)-1-[4-(2,5-difluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino}phenoxy)pyridin-2-ylcarbamoyl]ethyl acetate 
• 1345848-30-7 (S)-N-(2,5-difluoro-4-((2-(2-hydroxypropanamido)pyridin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1345848-32-9 N-(2,5-difluoro-4-((2-(2-fluoro-2-methylpropanamido)pyridin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1345847-77-9 N-[4-(2-chloropyridin-4-yloxy)-2,5-difluorophenyl]-N'-[4-fluorophenyl]cyclopropane-1,1-dicarboxamide 
• 1345847-79-1 N-(4-(2-acetamidopyridin-4-yloxy)-2,5-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1345847-81-5 N-(5-chloro-4-(2-chloropyridin-4-yloxy)-2-fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1345847-83-7 N-(4-(2-acetamidopyridin-4-yloxy)-5-chloro-2-fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1345847-89-3 N-(4-(2-(2-(dimethylamino)acetamido)pyridin-4-yloxy)-2,5-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1345847-93-9 N-(4-(2-(cyclopropanecarboxamido)pyridin-4-yloxy)-2,5-difluorophenyl)-N’-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1345847-95-1 N-(2,5-difluoro-4-(2-propionamidopyridin-4-yloxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1345848-00-1 N-(4-(2-acetamidopyridin-4-yloxy)-2-fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1345848-02-3 tert-butyl [4-(2,5-difluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino}phenoxy)pyridin-2-yl]carbamate 

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