5β-androstane-3α,17α-diyl 17-(pentafluorobenzoate) 3-[O⁵-tert-butyl-N-(tert-butoxycarbonyl)-L-glutamate]

Base Information

• Chemical Name: 5β-androstane-3α,17α-diyl 17-(pentafluorobenzoate) 3-[O⁵-tert-butyl-N-(tert-butoxycarbonyl)-L-glutamate]
• CAS No.: 1408057-17-9
• Molecular Formula: C₄₀H₅₄F₅NO₈
• Molecular Weight: 771.863

Synonyms:5β-androstane-3α,17α-diyl 17-(pentafluorobenzoate) 3-[O⁵-tert-butyl-N-(tert-butoxycarbonyl)-L-glutamate]

Chemical Property of 5β-androstane-3α,17α-diyl 17-(pentafluorobenzoate) 3-[O⁵-tert-butyl-N-(tert-butoxycarbonyl)-L-glutamate]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5β-androstane-3α,17α-diyl 17-(pentafluorobenzoate) 3-[O⁵-tert-butyl-N-(tert-butoxycarbonyl)-L-glutamate]

There total 2 articles about 5β-androstane-3α,17α-diyl 17-(pentafluorobenzoate) 3-[O⁵-tert-butyl-N-(tert-butoxycarbonyl)-L-glutamate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

Boc-Glu(OtBu)-OH (13726-84-6) + 3α-hydroxy-5β-androstan-17α-yl pentafluorobenzoate (1408057-16-8) → 5β-androstane-3α,17α-diyl 17-(pentafluorobenzoate) 3-[O5-tert-butyl-N-(tert-butoxycarbonyl)-L-glutamate] (1408057-17-9)

Guidance literature:

With dmap; diisopropyl-carbodiimide; In dichloromethane; Inert atmosphere;

DOI:10.1016/j.steroids.2012.07.004

Reference yield:

5beta-Androstane-17alpha-ol-3-one (5692-03-5) → 5β-androstane-3α,17α-diyl 17-(pentafluorobenzoate) 3-[O5-tert-butyl-N-(tert-butoxycarbonyl)-L-glutamate] (1408057-17-9)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap; diisopropyl-carbodiimide / dichloromethane / Inert atmosphere

2: cerium(III) chloride heptahydrate; sodium tetrahydroborate / methanol; ethyl acetate / 0.25 h / 20 °C

3: dmap; diisopropyl-carbodiimide / dichloromethane / Inert atmosphere

With dmap; sodium tetrahydroborate; cerium(III) chloride heptahydrate; diisopropyl-carbodiimide; In methanol; dichloromethane; ethyl acetate;

DOI:10.1016/j.steroids.2012.07.004

Reference yield: 96.0%

5β-androstane-3α,17α-diyl 17-(pentafluorobenzoate) 3-[O5-tert-butyl-N-(tert-butoxycarbonyl)-L-glutamate] (1408057-17-9) → 5β-androstane-3α,17α-diyl 17-(pentafluorobenzoate) 3-(L-glutamate) (1408057-18-0)

Guidance literature:

5β-androstane-3α,17α-diyl 17-(pentafluorobenzoate) 3-[O⁵-tert-butyl-N-(tert-butoxycarbonyl)-L-glutamate]; With trifluoroacetic acid; at 20 ℃; for 0.166667h;

With pyridine; In methanol; water; at 5 ℃;

DOI:10.1016/j.steroids.2012.07.004

upstream raw materials:

5beta-Androstane-17alpha-ol-3-one

Boc-Glu(OtBu)-OH

3α-hydroxy-5β-androstan-17α-yl pentafluorobenzoate

Downstream raw materials:

5β-androstane-3α,17α-diyl 17-(pentafluorobenzoate) 3-(L-glutamate)

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1408057-17-9 5β-androstane-3α,17α-diyl 17-(pentafluorobenzoate) 3-[O⁵-tert-butyl-N-(tert-butoxycarbonyl)-L-glutamate]

Send

Send

Metric Ton KG G Pound L ML

Send

Send