N-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,5-dimethyl-N-[1-methyl-1-(tetrahydro-pyran-4-yl)-ethyl]-benzamide

Base Information

Chemical Name:N-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,5-dimethyl-N-[1-methyl-1-(tetrahydro-pyran-4-yl)-ethyl]-benzamide
CAS No.:179096-60-7
Molecular Formula:C₃₅H₄₇NO₃Si
Molecular Weight:557.849
Hs Code.:

Synonyms:N-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,5-dimethyl-N-[1-methyl-1-(tetrahydro-pyran-4-yl)-ethyl]-benzamide

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Chemical Property of N-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,5-dimethyl-N-[1-methyl-1-(tetrahydro-pyran-4-yl)-ethyl]-benzamide

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Technology Process of N-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,5-dimethyl-N-[1-methyl-1-(tetrahydro-pyran-4-yl)-ethyl]-benzamide

There total 6 articles about N-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,5-dimethyl-N-[1-methyl-1-(tetrahydro-pyran-4-yl)-ethyl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 22328-43-4
2,5-dimethylbenzoyl chloride

: 179097-05-3
[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-[1-methyl-1-(tetrahydro-pyran-4-yl)-ethyl]-amine

: 179096-60-7
N-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,5-dimethyl-N-[1-methyl-1-(tetrahydro-pyran-4-yl)-ethyl]-benzamide

Guidance literature:: With triethylamine; In dichloromethane; for 24h; Ambient temperature;
DOI:10.1021/jm960092w

Reference yield:

: 179096-71-0
1-methyl-1-(tetrahydropyran-4-yl)ethylamine

: 179096-60-7
N-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,5-dimethyl-N-[1-methyl-1-(tetrahydro-pyran-4-yl)-ethyl]-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LiClO₄ / 1.) THF, 0 deg C, 5 min, 2.) THF, CH₃CN, RT, 4 h

2: 66 percent / imidazole / CH₂Cl₂ / 2 h / Ambient temperature

3: 68 percent / Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

With 1H-imidazole; lithium perchlorate; triethylamine; In dichloromethane;
DOI:10.1021/jm960092w

Reference yield:

: 179096-59-4
2-(tetrahydropyran-4-yl)propan-2-ol

: 179096-60-7
N-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,5-dimethyl-N-[1-methyl-1-(tetrahydro-pyran-4-yl)-ethyl]-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: AcOH, H₂SO₄ / 1.) 15 deg C, 45 min, 2.) 80 deg C, 2 h

2: conc. HCl / H₂O / 2.75 h / Heating

3: 1.) LiClO₄ / 1.) THF, 0 deg C, 5 min, 2.) THF, CH₃CN, RT, 4 h

4: 66 percent / imidazole / CH₂Cl₂ / 2 h / Ambient temperature

5: 68 percent / Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; sulfuric acid; lithium perchlorate; acetic acid; triethylamine; In dichloromethane; water;
DOI:10.1021/jm960092w