[(R)-1-((3aR,4R,6R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-allyl]-carbamic acid benzyl ester

Base Information

Chemical Name:[(R)-1-((3aR,4R,6R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-allyl]-carbamic acid benzyl ester
CAS No.:213973-69-4
Molecular Formula:C₁₉H₂₅NO₆
Molecular Weight:363.411
Hs Code.:

Synonyms:[(R)-1-((3aR,4R,6R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-allyl]-carbamic acid benzyl ester

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Chemical Property of [(R)-1-((3aR,4R,6R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-allyl]-carbamic acid benzyl ester

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Technology Process of [(R)-1-((3aR,4R,6R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-allyl]-carbamic acid benzyl ester

There total 12 articles about [(R)-1-((3aR,4R,6R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-allyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 77-76-9
2,2-dimethoxy-propane

: 358673-49-1
benzyl 5-(R)-N-Cbz-5,6-dideoxy-2,3-O-isopropylidene-β-D-ribo-hept-6-enfuranoside

: 213973-69-4
[(R)-1-((3aR,4R,6R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-allyl]-carbamic acid benzyl ester

Guidance literature:: With hydrogenchloride; In methanol; acetone; at 60 ℃; for 24h;
DOI:10.1016/S0040-4039(01)00735-3

Reference yield:

: (R)-2-((3aR,4R,6R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-but-3-enal

: 213973-69-4
[(R)-1-((3aR,4R,6R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-allyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaClO₂, Me₂C=CHMe, NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 12 h / 23 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol;
DOI:10.1021/jo9808066

Reference yield:

: 213973-68-3
(S)-2-((3aR,4R,6R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-but-3-en-1-ol

: 213973-69-4
[(R)-1-((3aR,4R,6R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-allyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) oxalyl chloride, DMSO, 2.) DIPEA / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) CH₂Cl₂, -78 deg C to rt, 30 min

2: NaClO₂, Me₂C=CHMe, NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 12 h / 23 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In water; tert-butyl alcohol;
DOI:10.1021/jo9808066