ethyl (R)-3-(tert-butyldiphenylsilyloxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate

Base Information

• Chemical Name: ethyl (R)-3-(tert-butyldiphenylsilyloxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate
• CAS No.: 1029915-61-4
• Molecular Formula: C₄₂H₄₅O₄PSi
• Molecular Weight: 672.876

Synonyms:ethyl (R)-3-(tert-butyldiphenylsilyloxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate

Chemical Property of ethyl (R)-3-(tert-butyldiphenylsilyloxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate

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Technology Process of ethyl (R)-3-(tert-butyldiphenylsilyloxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate

There total 2 articles about ethyl (R)-3-(tert-butyldiphenylsilyloxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(R)-3-(tert-butyldiphenylsilyloxy)-5-ethoxy-5-oxopentanoic (ethyl carbonic) anhydride (1029915-59-0) + Methyltriphenylphosphonium bromide (1779-49-3) → ethyl (R)-3-(tert-butyldiphenylsilyloxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate (1029915-61-4)

Guidance literature:

Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃;

(R)-3-(tert-butyldiphenylsilyloxy)-5-ethoxy-5-oxopentanoic (ethyl carbonic) anhydride; In tetrahydrofuran; hexane; at -78 - 0 ℃;

DOI:10.1002/ejoc.200701059

Reference yield: 45.0%

C25H32O7Si (1029915-57-8) + Methyltriphenylphosphonium bromide (1779-49-3) → ethyl (R)-3-(tert-butyldiphenylsilyloxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate (1029915-61-4)

Guidance literature:

Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; at -78 - 0 ℃;

C₂₅H₃₂O₇Si; In tetrahydrofuran; at -78 - 0 ℃;

DOI:10.1002/chir.20782

Reference yield: 70.0%

ethyl (R)-3-(tert-butyldiphenylsilyloxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate (1029915-61-4) + N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide (147118-37-4) → ethyl (3R,6E)-3-(tert-butyldiphenylsilyloxy)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methanesulfonyl)amino]pyrimidin-5-yl]-5-oxohept-6-enoate (1031246-52-2)

Guidance literature:

In acetonitrile; for 14h; Heating;

DOI:10.1002/ejoc.200700813

upstream raw materials:

(R)-3-(tert-butyldiphenylsilyloxy)-5-ethoxy-5-oxopentanoic (ethyl carbonic) anhydride

Methyltriphenylphosphonium bromide

C₂₅H₃₂O₇Si

Downstream raw materials:

ethyl (3R,6E)-3-(tert-butyldiphenylsilyloxy)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methanesulfonyl)amino]pyrimidin-5-yl]-5-oxohept-6-enoate

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