Technology Process of 7-chloro-3-(4-methoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole
There total 3 articles about 7-chloro-3-(4-methoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
7-chloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole;
With
2,2,6,6-tetramethylpiperidinylmagnesium chloride; zinc(II) chloride;
In
tetrahydrofuran;
at 25 ℃;
for 2h;
Inert atmosphere;
para-iodoanisole;
With
trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium(0);
In
tetrahydrofuran;
at 50 ℃;
for 12h;
regioselective reaction;
Inert atmosphere;
DOI:10.1039/c2cc17804d
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane; water / 3 h / Inert atmosphere
2.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride; zinc(II) chloride / tetrahydrofuran / 2 h / 25 °C / Inert atmosphere
2.2: 12 h / 50 °C / Inert atmosphere
With
2,2,6,6-tetramethylpiperidinylmagnesium chloride; tetrabutylammomium bromide; sodium hydroxide; zinc(II) chloride;
In
tetrahydrofuran; dichloromethane; water;
2.2: Negishi coupling reaction;
DOI:10.1039/c2cc17804d
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane; water / 3 h / Inert atmosphere
2.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride; zinc(II) chloride / tetrahydrofuran / 2 h / 25 °C / Inert atmosphere
2.2: 12 h / 50 °C / Inert atmosphere
With
2,2,6,6-tetramethylpiperidinylmagnesium chloride; tetrabutylammomium bromide; sodium hydroxide; zinc(II) chloride;
In
tetrahydrofuran; dichloromethane; water;
2.2: Negishi coupling reaction;
DOI:10.1039/c2cc17804d
