37435-12-4

Basic information

• Product Name: 7-CHLORO-1H-INDAZOLE
• Synonyms: 7-CHLOROINDAZOLE;1H-Indazole, 7-chloro-;7-CHLORO-1H-INDAZOLE
• CAS NO: 37435-12-4
• Molecular Formula: C₇H₅ClN₂
• Molecular Weight: 152.58
• Mol File: 37435-12-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 135-137
• Boiling Point: 309.536 °C at 760 mmHg
• Flash Point: 169.922 °C
• Appearance: /
• Density: 1.425 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.703
• Storage Temp.: 2-8°C
• PKA: 11.93±0.40(Predicted)
• CAS DataBase Reference: 7-CHLORO-1H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CHLORO-1H-INDAZOLE(37435-12-4)
• EPA Substance Registry System: 7-CHLORO-1H-INDAZOLE(37435-12-4)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 37435-12-4(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron, 50, p. 3529, 1994 DOI: 10.1016/S0040-4020(01)87030-7

InChI:InChI=1/C7H5ClN2/c8-6-3-1-2-5-4-9-10-7(5)6/h1-4H,(H,9,10)

Upstream product

• 90272-86-9 1-acetyl-7-chloro-1H-indazole 
• 1927-94-2 3-chlorosalicylaldehyde 
• 87-63-8 2-chloro-6-methylaniline 
• 85070-48-0 2-fluoro-3-chlorobenzaldehyde 

Downstream Products

• 885522-00-9 7-chloro-3-iodo-1H-indazole 
• 1361332-09-3 4-(7-chloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)benzonitrile 
• 1361332-05-9 7-chloro-3-(4-methoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole 

Relevant articles and documents

INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS

Provided herein are compounds of formula (V) that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.

An efficient synthesis of 1-H indazoles

The reaction of substituted salicyaldehydes with hydrazine hydrochloride under different conditions gave the corresponding 1-H indazoles. However, the reaction of benzaldehydes with hydrazine hydrate under the same conditions yielded only hydrazones.

New practical synthesis of indazoles via condensation of o-fluorobenzaldehydes and their O-methyloximes with hydrazine

The reaction of o-fluorobenzaldehydes and their O-methyloximes with hydrazine has been developed as a new practical synthesis of indazoles. Utilization of the methyloxime derivatives of benzaldehydes (in the form of the major E-isomers) in this condensation effectively eliminated a competitive Wolf-Kishner reduction to fluorotoluenes, which was observed in the direct preparations of indazoles from aldehydes. Reaction of Z-isomers of methyloximes with hydrazine resulted in the formation of 3-aminoindazoles via a benzonitrile intermediate.