4--1-naphthol

Base Information

• Chemical Name: 4--1-naphthol
• CAS No.: 221017-18-1
• Molecular Formula: C₂₇H₂₃N₃O₅
• Molecular Weight: 469.497
• Mol file: 221017-18-1.mol

Synonyms:4--1-naphthol

Chemical Property of 4--1-naphthol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4--1-naphthol

There total 1 articles about 4--1-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-amino-1-naphthol hydrochloride (5959-56-8) + N,N-bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine (152120-55-3) → 4--1-naphthol (221017-18-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; Ambient temperature;

DOI:10.1248/cpb.47.104

Reference yield: 87.0%

3-(tert-butyloxycarbonylamino)propionic acid (3303-84-2) + 4--1-naphthol (221017-18-1) → C35H36N4O8 (221017-24-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; a) 0 deg C, 1 h, b) RT, 12 h;

DOI:10.1248/cpb.47.104

Reference yield: 81.0%

L-N-Boc-Ala (15761-38-3) + 4--1-naphthol (221017-18-1) → C35H36N4O8 (221017-22-7)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; a) 0 deg C, 1 h, b) RT, 12 h;

DOI:10.1248/cpb.47.104

upstream raw materials:

4-amino-1-naphthol hydrochloride

N,N-bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine

Downstream raw materials:

C₃₅H₃₆N₄O₈

C₃₅H₃₆N₄O₈

C₃₆H₃₈N₄O₈

C₃₅H₃₆N₄O₈