152120-55-3

Usage

Uses

Used in Pharmaceutical Industry:
N,N'-BIS-Z-1-GUANYLPYRAZOLE is used as a pharmaceutical intermediate for the development of various drugs. Its role in the pharmaceutical industry is crucial, as it serves as a building block in the synthesis of new and innovative medications that can potentially treat a wide range of medical conditions.
As a pharmaceutical intermediate, N,N'-BIS-Z-1-GUANYLPYRAZOLE is involved in the production of various drugs, including those that target specific diseases or conditions. Its chemical properties make it a valuable component in the development of new pharmaceuticals, contributing to the advancement of medical treatments and therapies.

Upstream product

• 75315-63-8 N-(benzyloxycarbonyl)succinimide 
• 152120-62-2 (N)-benzyloxycarbonyl-1H-pyrazole-1-carboxamidine 
• 152120-62-2 N-benzyloxycarbonyl-1H-pyrrazole-1-carboxamidine 
• 501-53-1 benzyl chloroformate 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 

Downstream Products

• 152120-59-7 C₂₃H₂₁N₃O₄ 
• 174359-58-1 N^α-(tert-butyloxycarbonyl)glycylglycine p-(N',N''-bis(benzyloxycarbonyl)guanidino)phenyl ester 
• 174359-60-5 C₃₃H₃₇N₅O₉ 
• 181117-79-3 4-[N',N''-bis(benzyloxycarbonyl)guanidino]phenol 
• 221017-18-1 4--1-naphthol 
• 221017-19-2 5--1-naphthol 
• 221017-20-5 5--2-naphthol 
• 221017-21-6 6--1-naphthol 
• 172965-79-6 N^α-(N,N'-bis-Cbz)amidino-Tyr(Bn)-D-Arg(Cbz2)-Phe-OTce 
• 253177-00-3 (2S,3R)-3-(1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-azetidin-3-ylmethyl)-4-oxo-azetidine-2-carboxylic acid benzyl ester 
• 479622-23-6 (2S,3R)-3-(1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-pyrrolidin-3-ylmethyl)-4-oxo-azetidine-2-carboxylic acid benzyl ester 
• 384830-18-6 (2S,3R)-3-(1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-piperidin-3-ylmethyl)-4-oxo-azetidine-2-carboxylic acid benzyl ester 
• 384830-10-8 (2S,3R)-3-((S)-1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-piperidin-3-ylmethyl)-4-oxo-azetidine-2-carboxylic acid benzyl ester 
• 384830-05-1 (2S,3R)-3-((R)-1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-piperidin-3-ylmethyl)-4-oxo-azetidine-2-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Diaminopyrimidines as P2X3 and P2X2/3 modulators

Compounds of formula (I): wherein R1 and R2 are as defined herein. Also disclosed are methods of making and using the subject compounds.

An efficient method for the preparation of ω,ω'-bis-urethane protected arginine derivatives

Fmoc-Arg(ω,w')(Boc)2-OH and Boc-Arg(ω,w')(Cbz)2-OH were prepared in two steps: Guanylation of Cu(II)-ornithine complex at N(δ) with N,N'-bis urethane protected derivatives of 1-guanylpyrazole, followed by N(α)-protection using either 9-fluorenylmethyl succinimidylcarbonate or di-t-butyl-dicarbonate in the presence of EDTA. The overall yields of these products (2 steps) were 65% and 73%.

Urethane protected derivatives of 1-guanylpyrazole for the mild and efficient preparation of guanidines

Bis-urethane protected derivatives of 1-guanylpyrazole were prepared and found to readily react with relatively amines at room temperature to produce bis-protected guanidines in good yields. Simultaneous removal of both protecting groups from these products efficiently produced monosubstituted guanadines.