1-(5-(4-((1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-methoxyphenyl)-3(4-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone

Base Information

Chemical Name:1-(5-(4-((1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-methoxyphenyl)-3(4-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone
CAS No.:1415219-22-5
Molecular Formula:C₂₈H₂₅BrN₆O₅
Molecular Weight:605.448
Hs Code.:

Synonyms:1-(5-(4-((1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-methoxyphenyl)-3(4-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone

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Chemical Property of 1-(5-(4-((1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-methoxyphenyl)-3(4-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone

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Technology Process of 1-(5-(4-((1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-methoxyphenyl)-3(4-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone

There total 6 articles about 1-(5-(4-((1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-methoxyphenyl)-3(4-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1415219-53-2
1-(3-(4-Bromophenyl)-4,5-dihydro-5-(3-methoxy-4-(prop-2-ynyloxy)phenyl)pyrazol-1-yl)ethanone

: 17271-88-4
p-nitrobenzyl azide

: 1415219-22-5
1-(5-(4-((1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-methoxyphenyl)-3(4-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium ascorbate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; regioselective reaction;
DOI:10.1007/s00044-012-0312-7

Reference yield:

: (2E)-1-(4-bromophenyl)-3-(4-hydroxy-3-methoxyphenyl) prop-2-en-1-one

: 1415219-22-5
1-(5-(4-((1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-methoxyphenyl)-3(4-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / 4 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 24 h / 0 °C

3: copper(ll) sulfate pentahydrate; sodium ascorbate / N,N-dimethyl-formamide / 2 h / 20 °C

With copper(ll) sulfate pentahydrate; sodium ascorbate; potassium carbonate; hydrazine hydrate; In N,N-dimethyl-formamide; 3: |Huisgen Cycloaddition;
DOI:10.1007/s00044-012-0312-7

Reference yield:

: 99-90-1
para-bromoacetophenone

: 1415219-22-5
1-(5-(4-((1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-methoxyphenyl)-3(4-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; sulfuric acid / 48 h / 5 °C

2: hydrazine hydrate / 4 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 24 h / 0 °C

4: copper(ll) sulfate pentahydrate; sodium ascorbate / N,N-dimethyl-formamide / 2 h / 20 °C

With copper(ll) sulfate pentahydrate; sulfuric acid; sodium ascorbate; potassium carbonate; hydrazine hydrate; acetic acid; In N,N-dimethyl-formamide; 4: |Huisgen Cycloaddition;
DOI:10.1007/s00044-012-0312-7