2-bromo-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-fluorobenzene

Base Information

• Chemical Name: 2-bromo-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-fluorobenzene
• CAS No.: 1037088-98-4
• Molecular Formula: C₁₂H₁₈BrFOSi
• Molecular Weight: 305.262
• Mol file: 1037088-98-4.mol

Synonyms:2-bromo-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-fluorobenzene

Chemical Property of 2-bromo-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-fluorobenzene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-fluorobenzene

There total 1 articles about 2-bromo-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-bromo-4-fluorophenol (27407-11-0) + tert-butyldimethylsilyl chloride (18162-48-6) → 2-bromo-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-fluorobenzene (1037088-98-4)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 20 ℃; for 3h;

Reference yield: 69.0%

2-bromo-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-fluorobenzene (1037088-98-4) + C11H12N2O2 → C23H31FN2O3Si

Guidance literature:

2-bromo-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-fluorobenzene; With isopropylmagnesium chloride; In tetrahydrofuran; at -20 - 5 ℃; for 1h; Inert atmosphere;

C₁₁H₁₂N₂O₂; In tetrahydrofuran; at -40 - 20 ℃;

Reference yield: 51.2%

2-((dimethylamino)methyl)-bicyclo[3.2.1]octan-3-one + 2-bromo-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-fluorobenzene (1037088-98-4) → 2-((dimethylamino)methyl)-3-(2-fluoro-5-hydroxy-phenyl)-bicyclo[3.2.1]octan-3-ol

Guidance literature:

2-bromo-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-fluorobenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

2-((dimethylamino)methyl)-bicyclo[3.2.1]octan-3-one; With hydrogenchloride; In tetrahydrofuran; water; at -78 ℃; for 1h;

upstream raw materials:

3-bromo-4-fluorophenol

tert-butyldimethylsilyl chloride

Downstream raw materials:

5-dimethylaminomethyl-6-(2-fluoro-5-hydroxy-phenyl)-spiro[2.5]octan-6-ol

5-dimethylaminomethyl-6-(2-fluoro-5-hydroxy-phenyl)-spiro[2.5]octan-6-ol hydrochloride