(R)-2-Amino-2,4-dimethylpentanoic acid

Base Information

• Chemical Name: (R)-2-Amino-2,4-dimethylpentanoic acid
• CAS No.: 29589-03-5
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.202
• Hs Code.: 2922499990
• European Community (EC) Number: 871-320-3
• UNII: 5I6LNK6551
• Nikkaji Number: J263.664F
• Mol file: 29589-03-5.mol

Synonyms:29589-03-5;(R)-2-AMINO-2,4-DIMETHYLPENTANOIC ACID;H-ALPHA-ME-D-LEU-OH;D-Leucine, 2-methyl-;(2R)-2-amino-2,4-dimethylpentanoic acid;(R)-ALPHA-METHYLLEUCINE;2-METHYL-D-LEUCINE;5I6LNK6551;alpha-Methyl-D-leucine;H--Me-D-Leu-OH;alpha-Methylleucine, D-;H-|A-Me-D-Leu-OH;(R)-A-METHYLLEUCINE;alpha-Methylleucine, (-)-;H-ALFA-ME-D-LEU-OH;SCHEMBL160650;UNII-5I6LNK6551;(R)-.ALPHA.-METHYLLEUCINE;.ALPHA.-METHYLLEUCINE, D-;BCP28407;MFCD08752476;AKOS025290465;.ALPHA.-METHYLLEUCINE, (-)-;AB48913;AM10149;FD21917;AS-57287;CS-0186121;A876428

Chemical Property of (R)-2-Amino-2,4-dimethylpentanoic acid

Chemical Property:

• PSA: 63.32000
• LogP: 1.53480
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 145.110278721
• Heavy Atom Count: 10
• Complexity: 134

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-Amino-2,4-dimethylpentanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C)(C(=O)O)N
• Isomeric SMILES: CC(C)C[C@](C)(C(=O)O)N

Technology Process of (R)-2-Amino-2,4-dimethylpentanoic acid

There total 8 articles about (R)-2-Amino-2,4-dimethylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.3%

D-α-methylleucine amide (113565-54-1) → (R)-α-methyl-leucine (29589-03-5)

Guidance literature:

With hydrogenchloride; at 90 ℃; for 72h;

DOI:10.1021/jo00243a049

Reference yield:

C14H19N3O2 → (R)-α-methyl-leucine (29589-03-5) + (S)-2-amino-2,4-dimethylpentanoic acid (105743-53-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.01.041

Reference yield:

(3S,9bR)-3-Isobutyl-3-methyl-9bH-1,5-dioxa-3a-aza-cyclopenta[a]naphthalene-2,4-dione (129786-65-8) → (R)-α-methyl-leucine (29589-03-5) + (S)-2-amino-2,4-dimethylpentanoic acid (105743-53-1)

Guidance literature:

With lithium hydroxide; In 1,4-dioxane; water; at 25 ℃; for 0.333333h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00307a008

upstream raw materials:

(3S,9bR)-3-Isobutyl-3-methyl-9bH-1,5-dioxa-3a-aza-cyclopenta[a]naphthalene-2,4-dione

D-α-methylleucine amide

(R)-2,4-Dimethyl-2-((4S,5R)-2-oxo-4,5-diphenyl-oxazolidin-3-yl)-pentanoic acid

(R)-2,4-Dimethyl-2-((4S,5R)-2-oxo-4,5-diphenyl-oxazolidin-3-yl)-pentanal