N⁴-Anisoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine

Base Information

• Chemical Name: N⁴-Anisoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine
• CAS No.: 93134-39-5
• Molecular Formula: C₄₄H₅₁N₃O₈Si
• Molecular Weight: 777.99

Synonyms:N⁴-Anisoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine

Chemical Property of N⁴-Anisoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine

Chemical Property:

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Technology Process of N⁴-Anisoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine

There total 1 articles about N⁴-Anisoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N4-anisoyl-5'-O-(4,4'-dimethoxytrityl) 2'-deoxy cytidine (68892-40-0) + tert-butyldimethylsilyl chloride (18162-48-6) → N4-Anisoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine (93134-39-5)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 1h;

DOI:10.1021/jo00199a032

Reference yield: 74.0%

N4-Anisoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine (93134-39-5) → N4-Anisoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine (93134-42-0)

Guidance literature:

With zinc dibromide; In methanol; dichloromethane; for 0.5h;

DOI:10.1021/jo00199a032

Reference yield:

N4-Anisoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine (93134-39-5) → C56H55N8O14P (93134-62-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / ZnBr₂ / methanol; CH₂Cl₂ / 0.5 h

2: 74 percent / tetrazole / acetonitrile / 0.25 h / ice bath

3: 1.) aq. iodine 2.) tetrabutylammonium fluoride

With 1H-tetrazole; tetrabutyl ammonium fluoride; iodine; zinc dibromide; In methanol; dichloromethane; acetonitrile;

DOI:10.1021/jo00199a032

upstream raw materials:

N⁴-anisoyl-5'-O-(4,4'-dimethoxytrityl) 2'-deoxy cytidine

tert-butyldimethylsilyl chloride

Downstream raw materials:

N⁴-Anisoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine

C₅₆H₅₅N₈O₁₄P

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