4-Amino-1-[(2R,3S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one

Base Information

• Chemical Name: 4-Amino-1-[(2R,3S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one
• CAS No.: 82845-99-6
• Molecular Formula: C₃₆H₄₅N₃O₇Si
• Molecular Weight: 659.855
• Mol file: 82845-99-6.mol

Synonyms:4-Amino-1-[(2R,3S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one

Chemical Property of 4-Amino-1-[(2R,3S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Amino-1-[(2R,3S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one

There total 3 articles about 4-Amino-1-[(2R,3S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-Amino-1-{(2R,3S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-1H-pyrimidin-2-one (82845-90-7) + tert-butyldimethylsilyl chloride (18162-48-6) → 4-Amino-1-[(2R,3S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one (82845-99-6) + 4-Amino-1-[(2R,3S,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one (82845-95-2)

Guidance literature:

With triethylamine; silver nitrate; In 1,2-dimethoxyethane; for 3h;

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 4-Amino-1-[(2R,3S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one (82845-99-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / pyridine / dimethylformamide / 1 h / -5 °C

2: 4 percent / triethylamine / silver nitrate / 1,2-dimethoxy-ethane / 3 h

With pyridine; triethylamine; silver nitrate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;

Reference yield:

arabinosyl cytosine (147-94-4) → 4-Amino-1-[(2R,3S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one (82845-99-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / pyridine / dimethylformamide / 1 h / -5 °C

2: 4 percent / triethylamine / silver nitrate / 1,2-dimethoxy-ethane / 3 h

With pyridine; triethylamine; silver nitrate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;

upstream raw materials:

4-Amino-1-{(2R,3S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-1H-pyrimidin-2-one

tert-butyldimethylsilyl chloride

4,4'-dimethoxytrityl chloride

arabinosyl cytosine