methyl 3'-((4R,5R)-5-((5R,Z)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-en-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate

Base Information

Chemical Name:methyl 3'-((4R,5R)-5-((5R,Z)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-en-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate
CAS No.:1606132-38-0
Molecular Formula:C₃₄H₅₀O₉Si
Molecular Weight:630.851
Hs Code.:

methyl 3'-((4R,5R)-5-((5R,Z)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-en-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate

Synonyms:methyl 3'-((4R,5R)-5-((5R,Z)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-en-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate

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Chemical Property of methyl 3'-((4R,5R)-5-((5R,Z)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-en-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate

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Technology Process of methyl 3'-((4R,5R)-5-((5R,Z)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-en-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate

There total 14 articles about methyl 3'-((4R,5R)-5-((5R,Z)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-en-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1606132-36-8
methyl 3'-((4R,5R)-5-((5R)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-yn-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate

: 1606132-38-0
methyl 3'-((4R,5R)-5-((5R,Z)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-en-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate

Guidance literature:: With quinoline; rosenmund catalyst; hydrogen; In ethyl acetate; at 20 ℃; for 8h;

Reference yield:

: 1606132-34-6
C₂₁H₂₂O₈

: 1606132-38-0
methyl 3'-((4R,5R)-5-((5R,Z)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-en-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 6 h / 40 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

3.1: methanol; sodium tetrahydroborate / 4 h / 20 °C

4.1: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 3 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran / 1.5 h / -78 °C

5.2: 4 h / -78 °C

6.1: hydrogen; quinoline; rosenmund catalyst / ethyl acetate / 8 h / 20 °C

With quinoline; methanol; sodium tetrahydroborate; n-butyllithium; rosenmund catalyst; hydrogen; sodium hydrogencarbonate; potassium hydrogencarbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1606132-42-6
C₂₃H₂₆O₈

: 1606132-38-0
methyl 3'-((4R,5R)-5-((5R,Z)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-en-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 1.5 h / -78 °C

1.2: 4 h / -78 °C

2.1: hydrogen; quinoline; rosenmund catalyst / ethyl acetate / 8 h / 20 °C

With quinoline; n-butyllithium; rosenmund catalyst; hydrogen; In tetrahydrofuran; ethyl acetate;