methyl 3'-((4R,5R)-5-((5R)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-yn-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate

Base Information

Chemical Name:methyl 3'-((4R,5R)-5-((5R)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-yn-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate
CAS No.:1606132-36-8
Molecular Formula:C₃₄H₄₈O₉Si
Molecular Weight:628.835
Hs Code.:

methyl 3'-((4R,5R)-5-((5R)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-yn-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate

Synonyms:methyl 3'-((4R,5R)-5-((5R)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-yn-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate

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Chemical Property of methyl 3'-((4R,5R)-5-((5R)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-yn-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate

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Technology Process of methyl 3'-((4R,5R)-5-((5R)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-yn-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate

There total 14 articles about methyl 3'-((4R,5R)-5-((5R)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-yn-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1606132-42-6
C₂₃H₂₆O₈

: 193544-52-4
(R)-tert-butyl(dimethyl)(pent-4-yn-2-yloxy)silane

: 1606132-36-8
methyl 3'-((4R,5R)-5-((5R)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-yn-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate

Guidance literature:: (R)-tert-butyl(dimethyl)(pent-4-yn-2-yloxy)silane; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1.5h;

C₂₃H₂₆O₈; In tetrahydrofuran; at -78 ℃; for 4h;

Reference yield:

: 532394-17-5
7-methoxy-2,2-dimethyl-5-(trifluoromethylsulfonyloxy)benzo[1,3]dioxin-4-one

: 1606132-36-8
methyl 3'-((4R,5R)-5-((5R)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-yn-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium dihydrogenphosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 1 h / 85 °C

2.1: manganese(IV) oxide / chloroform / 6 h / 45 °C

3.1: dichloromethane; water / 0 °C

4.1: AD-mix β; tert-butyl alcohol; methanesulfonamide / water / 6 h / 20 °C

5.1: pyridinium p-toluenesulfonate / dichloromethane / 16 h / 20 °C

6.1: methanol; sodium methylate / tetrahydrofuran / 0.5 h / 0 - 20 °C

7.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 6 h / 40 °C

8.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

9.1: methanol; sodium tetrahydroborate / 4 h / 20 °C

10.1: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 3 h / 20 °C

11.1: n-butyllithium / tetrahydrofuran / 1.5 h / -78 °C

11.2: 4 h / -78 °C

With methanol; manganese(IV) oxide; sodium tetrahydroborate; potassium dihydrogenphosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; methanesulfonamide; AD-mix β; sodium methylate; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; potassium hydrogencarbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; tert-butyl alcohol; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 1606132-34-6
C₂₁H₂₂O₈

: 1606132-36-8
methyl 3'-((4R,5R)-5-((5R)-5-((tert-butyldimethylsilyl)oxy)-1-hydroxyhex-2-yn-1-yl)-2,2-dimethyl-1,3-dioxoran-4-yl)-5-methoxy-3-(methoxymethoxy)-[1,1'-biphenyl]-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 6 h / 40 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

3.1: methanol; sodium tetrahydroborate / 4 h / 20 °C

4.1: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 3 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran / 1.5 h / -78 °C

5.2: 4 h / -78 °C

With methanol; sodium tetrahydroborate; n-butyllithium; sodium hydrogencarbonate; potassium hydrogencarbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;