tert-butyl 5-cyclopropyl-3-(2-phenyl-5-((trimethylsilyl)ethynyl)pyrimidin-4-ylamino)-1H-pyrazole-1-carboxylate

Base Information

Chemical Name:tert-butyl 5-cyclopropyl-3-(2-phenyl-5-((trimethylsilyl)ethynyl)pyrimidin-4-ylamino)-1H-pyrazole-1-carboxylate
CAS No.:1266480-04-9
Molecular Formula:C₂₆H₃₁N₅O₂Si
Molecular Weight:473.65
Hs Code.:

Synonyms:tert-butyl 5-cyclopropyl-3-(2-phenyl-5-((trimethylsilyl)ethynyl)pyrimidin-4-ylamino)-1H-pyrazole-1-carboxylate

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Chemical Property of tert-butyl 5-cyclopropyl-3-(2-phenyl-5-((trimethylsilyl)ethynyl)pyrimidin-4-ylamino)-1H-pyrazole-1-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl 5-cyclopropyl-3-(2-phenyl-5-((trimethylsilyl)ethynyl)pyrimidin-4-ylamino)-1H-pyrazole-1-carboxylate

There total 6 articles about tert-butyl 5-cyclopropyl-3-(2-phenyl-5-((trimethylsilyl)ethynyl)pyrimidin-4-ylamino)-1H-pyrazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1266480-03-8
tert-butyl 5-cyclopropyl-3-(5-iodo-2-phenylpyrimidin-4-ylamino)-1H-pyrazole-1-carboxylate

: 1066-54-2
trimethylsilylacetylene

: 1266480-04-9
tert-butyl 5-cyclopropyl-3-(2-phenyl-5-((trimethylsilyl)ethynyl)pyrimidin-4-ylamino)-1H-pyrazole-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 15934-46-0
benzamidene hydrochloride

: 1266480-04-9
tert-butyl 5-cyclopropyl-3-(2-phenyl-5-((trimethylsilyl)ethynyl)pyrimidin-4-ylamino)-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / ethanol / 15 h / Reflux; Inert atmosphere

2.1: acetic acid; N-iodo-succinimide / 1 h / 50 °C

3.1: phosphorus(V) oxybromide / 8 h / 100 °C

4.1: butan-1-ol / 24 h / 90 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

5.2: 2 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With N-iodo-succinimide; sodium hydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; phosphorus(V) oxybromide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; ethanol; mineral oil; butan-1-ol;

Reference yield:

: 33643-94-6,127892-81-3
2-phenyl-4-hydroxypyrimidine

: 1266480-04-9
tert-butyl 5-cyclopropyl-3-(2-phenyl-5-((trimethylsilyl)ethynyl)pyrimidin-4-ylamino)-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; N-iodo-succinimide / 1 h / 50 °C

2.1: phosphorus(V) oxybromide / 8 h / 100 °C

3.1: butan-1-ol / 24 h / 90 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

4.2: 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With N-iodo-succinimide; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; phosphorus(V) oxybromide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; mineral oil; butan-1-ol;