15934-46-0

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 55-21-0 benzamide 
• 100-47-0 benzonitrile 
• 60199-37-3 N-benzoyl p-nitrobenzenesulfenamide 
• 81386-74-5 C₂₀H₁₅ClN₂O₂S 
• 7647-01-0 hydrogenchloride 
• 71151-37-6 p-chlorobenzene(N-benzoyl)iminosulfinyl chloride 
• 106-54-7 p-Chlorothiophenol 
• 68556-47-8 N-benzoyl-p-chlorobenzenesulfenamide 
• 70925-53-0 p-toluene(N-benzoyl)iminosulfinyl chloride 
• 106-45-6 para-thiocresol 

Downstream Products

• 1266476-82-7 N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-ethynyl-2-phenyl-pyrimidin-4-amine 
• 1266479-98-4 4,5-dibromo-2-phenylpyrimidine 
• 1266480-05-0 N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-phenyl-5-((trimethylsilyl)ethynyl)pyrimidin-4-amine 
• 1266480-03-8 tert-butyl 5-cyclopropyl-3-(5-iodo-2-phenylpyrimidin-4-ylamino)-1H-pyrazole-1-carboxylate 
• 1266477-07-9 (E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-(3-methoxyprop-1-enyl)-2-phenyl-pyrimidin-4-amine 
• 26786-28-7 5-bromo-4-hydroxy-2-phenylpyrimidine 
• 1266480-00-5 5-iodo-2-phenylpyrimidin-4-ol 
• 1266480-01-6 4-bromo-5-iodo-2-phenylpyrimidine 
• 1266480-02-7 N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-iodo-2-phenylpyrimidin-4-amine 
• 1266480-04-9 tert-butyl 5-cyclopropyl-3-(2-phenyl-5-((trimethylsilyl)ethynyl)pyrimidin-4-ylamino)-1H-pyrazole-1-carboxylate 
• 1266476-75-8 5-bromo-N-(5-cyclopropyl-2H-pyrazol-3-yl)-2-phenyl-pyrimidin-4-amine 
• 3749-46-0 2-phenyl-5-nitro-4-oxopyrimidine 
• 33643-94-6 2-phenyl-4-hydroxypyrimidine 
• 1227380-43-9 (S,S)-cyclohexenylimidazoline 

Relevant academic research and scientific papers

Efficient transformation of nitrile into amide under mild condition

Transformation of various kinds of nitriles into the corresponding amides or amide salts was performed in good yields by the addition of two equiv of chlorotrimethylsilane and two equiv of water at 0°C to 25°C.

New substituted heterocyclic benzamides, methods of preparing them and their application as behavior modifiers

There are provided new substituted heterocyclic benzamides and derivativeshereof which provide modifications on the central nervous system.

Benzamide derivative analgesics

Benzamide derivative analgesic compounds of the formula STR1 wherein P, Q, R1, R2, X and Y are as defined in the specification, e.g., 3,4-Dichloro-N-[[8-(dimethylamino)-1,4-dioxaspiro[4.5]dec-8-yl]methyl]benzamide, and their pharmaco

OXIDATION IMINATION OF SULFENYL CHLORIDES BY N-CHLOROCARBOXAMIDES. N-ACYLSULFINIMIDOYL CHLORIDES

The reaction of arenesulfenyl chlorides ArSCl with N-chlorocarboxyamides in a ratio of 1:1 leads to the formation of N-acylsulfinimidoyl chlorides ArS(=NCOR)Cl.The reaction of arenesulfenyl chlorides and N-chlorobenzamide in ratio of 1:1 leads to aryldibenzamidosulfonium chlorides ArS(NHCOC6H5)2, which are hydrolyzed with the formation of N,N'-benzoylarenesulfinamidines ArS(=NCOC6H5)NHCOC6H5 and are cleaved into acid chlorides and benzamide when heated.

CHEMISTRY OF IMINOSULFINIC ACIDS. REACTION OF N-ACYLIMINOSULFINYL CHLORIDES WITH THIOPHENOLS

Arene(N-benzoyl)- and arene(N-phenylsulfonyl)iminosulfinyl chlorides on reaction with thiophenols are reduced to N-(benzoyl) or N-(phenylsulfonyl)arenesulfenamides.When N-benzoyliminosulfinyl chlorides are reacted with thiophenols in the presence of triethylamine, a mixture of diaryl sulfides, NN-di(arylthio)benzamide, and N-arylthio-NN'-dibenzoylarenesulfinamidines is obtained.On heating, the latter reversibly dissociate to stable N-arylthio-N-benzoylaminyl radicals.

N-(1'-Allypyrrolidinyl 2'-methyl) 2-methoxy 4,5-azimido benzamide and its pharmaceutically acceptable salts

The azimido benzamide of this invention and its pharmaceutically acceptable salts have an unusually and unexpectedly high therapeutic index and low toxicity in the treatment of emesis in mammals. Pharmacological testing demonstrated the superior efficacy of the compound of this invention over known, similar compounds.