methyl (3S,4S,5S)-3--4,5-(isopropylidenedioxy)hexanoate

Base Information

Chemical Name:methyl (3S,4S,5S)-3--4,5-(isopropylidenedioxy)hexanoate
CAS No.:111524-24-4
Molecular Formula:C₂₄H₄₁NO₅Si
Molecular Weight:451.679
Hs Code.:

methyl (3S,4S,5S)-3-<N-(tert-butyldimethylsiloxy)-(1S)-1-phenylethylamino>-4,5-(isopropylidenedioxy)hexanoate

Synonyms:methyl (3S,4S,5S)-3--4,5-(isopropylidenedioxy)hexanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (3S,4S,5S)-3--4,5-(isopropylidenedioxy)hexanoate

Chemical Property:

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Technology Process of methyl (3S,4S,5S)-3--4,5-(isopropylidenedioxy)hexanoate

There total 16 articles about methyl (3S,4S,5S)-3--4,5-(isopropylidenedioxy)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 77086-38-5
ketene t-butyldimethylsilyl methyl acetal

: 111612-93-2
(Z)-((4R)-trans-2,2,5-trimethyl-1,3-dioxolan-4-yl)methylene((1S)-1-phenylethyl)amino N-oxide

: 111524-24-4
methyl (3S,4S,5S)-3--4,5-(isopropylidenedioxy)hexanoate

Guidance literature:: zinc(II) iodide; In dichloromethane; acetonitrile; at -78 ℃; for 1h;
DOI:10.1248/cpb.37.1446

Reference yield: 89.0%

: 77086-38-5
ketene t-butyldimethylsilyl methyl acetal

: 111524-15-3,184046-67-1
N-[((4S,5S)-2,2,5-trimethyl-1,3-dioxolan-4-yl)methylene]((1R)-1-phenylethyl)amine N-oxide

: 111524-21-1,111524-24-4,111687-35-5,125257-84-3
methyl (4S,5S)-3--4,5-(isopropylidenedioxy)hexanoate

Guidance literature:: zinc(II) iodide; In dichloromethane; acetonitrile; at -78 ℃; for 1h;
DOI:10.1248/cpb.37.1446

Reference yield:

: 41167-51-5,57626-73-0,67195-07-7,73679-52-4,73679-54-6,81739-14-2,111319-77-8,85249-45-2
(4S,5S)-4-hydroxymethyl-2,2,5-trimethyl-[1,3]-dioxolane

: 111524-24-4
methyl (3S,4S,5S)-3--4,5-(isopropylidenedioxy)hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) oxalyl chloride, 2.) triethylamine / 1.) DMSO, methylene chloride, 20 min, -78 deg C, 2.) DMSO, CH₂Cl₂, -78 deg C, 20 min, warm to room temperature

2: 67 percent / sodium sulfate / CH₂Cl₂ / 15 h / Ambient temperature

3: 100 percent / zinc iodide / acetonitrile; CH₂Cl₂ / 1 h / -78 °C

With oxalyl dichloride; sodium sulfate; triethylamine; zinc(II) iodide; In dichloromethane; acetonitrile;
DOI:10.1248/cpb.37.1446