(S)-1-Phenylethylhydroxylamine

Base Information

• Chemical Name: (S)-1-Phenylethylhydroxylamine
• CAS No.: 53933-47-4
• Molecular Formula: C8H11NO
• Molecular Weight: 137.181
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID60448101
• Nikkaji Number: J1.429.882G
• Wikidata: Q72501817
• Mol file: 53933-47-4.mol

Synonyms:53933-47-4;(S)-1-PHENYLETHYLHYDROXYLAMINE;(s)-n-(1-phenylethyl)hydroxylamine;N-[(1S)-1-phenylethyl]hydroxylamine;N-[(1S)-1-Phenethyl]hydroxylamine;N-((1S)-1-phenylethyl)hydroxylamine;SCHEMBL3984108;DTXSID60448101;RRJRFNUPXQLYHX-ZETCQYMHSA-N;AMY34227;(1S)-N-Hydroxy-1-phenylethanamine;MFCD08064283;N-[(S)-1-Phenylethyl]hydroxylamine;(s)-N-(a-phenyl-ethyl)-hydroxylamine;AKOS006280341;AKOS008901101;CS-0054046;P10551

Chemical Property of (S)-1-Phenylethylhydroxylamine

Chemical Property:

• Vapor Pressure: 0.011mmHg at 25°C
• Melting Point: 90-91 ºC
• Refractive Index: 1.546
• Boiling Point: 251 ºC
• PKA: 13.26±0.50(Predicted)
• Flash Point: 117 ºC
• PSA: 32.26000
• Density: 1.060
• LogP: 2.11730
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 89.3

Purity/Quality:

97% ^*data from raw suppliers

N-[(1S)-1-Phenethyl]hydroxylamine 90+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1)NO
• Isomeric SMILES: C[C@@H](C1=CC=CC=C1)NO

Technology Process of (S)-1-Phenylethylhydroxylamine

There total 37 articles about (S)-1-Phenylethylhydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(S)-1-phenyl-ethylamine (2627-86-3) → N-((1S)-1-phenylethyl)hydroxylamine (53933-47-4)

Guidance literature:

With urea hydrogen peroxide adduct; In diethyl ether; at 20 ℃; for 1h; Catalytic behavior; Inert atmosphere;

DOI:10.1039/d0nj00829j

Reference yield: 89.0%

acetophenone oxime (613-91-2) → N-(1-phenyl-ethyl)-hydroxylamine (2912-98-3,53933-47-4,67377-55-3,101314-62-9)

Guidance literature:

With Benzyltriethylammonium borohydride; at 20 ℃; for 0.216667h; solid-phase conditions;

DOI:10.1070/MC2006v016n01ABEH002213

Reference yield: 86.0%

(1S)-N-((4-methoxyphenyl)methylidene)-1-phenylethanamine + hydroxylamine hydrochloride (5470-11-1) + p-toluenesulfonic acid monohydrate (6192-52-5) → N-((1S)-1-phenylethyl)hydroxylamine (53933-47-4)

Guidance literature:

With m-chloroperoxybenzoic acid; In tetrahydrofuran; water; ethyl acetate;

upstream raw materials:

acetophenone oxime

N-α-methyl benzyl-O-benzoyl hydroxylamine hydrochloride

tin(II) benzenethiolate

(1-nitroethyl)benzene

Downstream raw materials:

C₉H₁₁NO

(R)-3-Methyl-2-((S)-1-phenyl-ethyl)-isoxazolidin-5-one

(S,S)-N(2)-α-methylbenzyl-3-methylisoxazolidin-5-one

methyl-3aminobutanoate