N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamide

Base Information

Chemical Name:N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamide
CAS No.:1496517-89-5
Molecular Formula:C₂₅H₄₀N₆O₇
Molecular Weight:536.629
Hs Code.:

Synonyms:N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamide

There total 7 articles about N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1578196-69-6
C₃₀H₄₈N₆O₉

: 1496517-89-5
N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/ja500170h

Reference yield:

: 4246-51-9
4,7,10-trioxa-1,13-diaminotridecane

: 1496517-89-5
N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 6 h / Inert atmosphere

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 5 °C

3: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja500170h

Reference yield:

: 21253-58-7
2,4-diamino-5-(3,5-dimethoxy-4-hydroxybenzyl)pyrimidine

: 1496517-89-5
N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol / 1 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 5 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With potassium tert-butylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja500170h