4-methyl-N-(((S)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidine-3-yl)methyl)benzamide

Base Information

Chemical Name:4-methyl-N-(((S)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidine-3-yl)methyl)benzamide
CAS No.:1615250-00-4
Molecular Formula:C₂₇H₃₃N₃O₃
Molecular Weight:447.577
Hs Code.:

Synonyms:4-methyl-N-(((S)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidine-3-yl)methyl)benzamide

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Chemical Property of 4-methyl-N-(((S)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidine-3-yl)methyl)benzamide

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Technology Process of 4-methyl-N-(((S)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidine-3-yl)methyl)benzamide

There total 7 articles about 4-methyl-N-(((S)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidine-3-yl)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1629057-45-9
(S)-5-((S)-3-(aminomethyl)piperidine-1-carbonyl)-1-(4-methylbenzyl)pyrrolidin-2-one

: 874-60-2
4-methyl-benzoyl chloride

: 1615250-00-4
4-methyl-N-(((S)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidine-3-yl)methyl)benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield:

: 87341-45-5
(2S)-N-(4-methylbenzyl) pyroglutamic acid

: 1615250-00-4
4-methyl-N-(((S)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidine-3-yl)methyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / dichloromethane / 12 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 0.17 h / 0 °C

2.2: 3 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

4.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

With oxalyl dichloride; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield:

: 104-81-4
4-Methylbenzyl bromide

: 1615250-00-4
4-methyl-N-(((S)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidine-3-yl)methyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C / Inert atmosphere

2.1: sodium carbonate; water / methanol / 5 h / 0 - 20 °C

3.1: oxalyl dichloride / dichloromethane / 12 h / 0 - 20 °C

4.1: triethylamine / dichloromethane / 0.17 h / 0 °C

4.2: 3 h / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

6.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

With oxalyl dichloride; water; sodium carbonate; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.05.017