(4-Ethylphenyl)methanamine hydrochloride

Base Information

• Chemical Name: (4-Ethylphenyl)methanamine hydrochloride
• CAS No.: 102494-85-9
• Molecular Formula: C₉H₁₃N*ClH
• Molecular Weight: 171.67
• European Community (EC) Number: 828-502-2
• Mol file: 102494-85-9.mol

Synonyms:(4-ethylphenyl)methanamine hydrochloride;102494-85-9;(4-ethylphenyl)methanamine;hydrochloride;starbld0039315;1-(4-ethylphenyl)methanamine hydrochloride;EN300-184079

Chemical Property of (4-Ethylphenyl)methanamine hydrochloride

Chemical Property:

• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 171.0814771
• Heavy Atom Count: 11
• Complexity: 82.7

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC1=CC=C(C=C1)CN.Cl

Technology Process of (4-Ethylphenyl)methanamine hydrochloride

There total 3 articles about (4-Ethylphenyl)methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-ethylbenzonitrile (25309-65-3) → (4-ethylphenyl)methanamine monohydrochloride (102494-85-9)

Guidance literature:

4-ethylbenzonitrile; With C₂₈H₂₉Cl₂CoNP₂; hydrogen; sodium triethylborohydride; In 1,4-dioxane; at 80 ℃; for 6h; under 37503.8 Torr;

With hydrogenchloride;

DOI:10.1039/c9cy00225a

Reference yield:

4-cyanophenyl methyl ketone (1443-80-7) → (4-ethylphenyl)methanamine monohydrochloride (102494-85-9)

Guidance literature:

4-cyanophenyl methyl ketone; With sodium hypophosphite monohydrate; 5%-palladium/activated carbon; hypophosphorous acid; In water; at 100 ℃; Sealed tube;

With hydrogenchloride; In diethyl ether;

DOI:10.1016/j.tet.2014.02.014

Reference yield:

C17H33NSi2 → (4-ethylphenyl)methanamine monohydrochloride (102494-85-9)

Guidance literature:

With hydrogenchloride; water; In diethyl ether; at 20 ℃; for 1h;

DOI:10.1021/acs.joc.5b00941

upstream raw materials:

4-cyanophenyl methyl ketone

4-ethylbenzonitrile

Downstream raw materials:

(S)-N-4-(ethyl)benzyl 2-(benzyloxycarbonyl)amino-3-hydroxypropionamide

(R)-N-4-(ethyl)benzyl 2-(benzyloxycarbonyl)amino-3-hydroxypropionamide

Refernces

• 1、 Gandhamsetty, Narasimhulu,Jeong, Jinseong,Park, Juhyeon,Park, Sehoon,Chang, Sukbok. "Boron-Catalyzed Silylative Reduction of Nitriles in Accessing Primary Amines and Imines". . p. 7281 - 7287. Retrieved 2015/07/28.