9H-fluoren-9-ylmethyl 4-[(3-bromo-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)carbonyl]piperidine-1-carboxylate

Base Information

Chemical Name:9H-fluoren-9-ylmethyl 4-[(3-bromo-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)carbonyl]piperidine-1-carboxylate
CAS No.:816464-44-5
Molecular Formula:C₃₄H₂₇BrN₂O₄S
Molecular Weight:639.569
Hs Code.:

Synonyms:9H-fluoren-9-ylmethyl 4-[(3-bromo-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)carbonyl]piperidine-1-carboxylate

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Chemical Property of 9H-fluoren-9-ylmethyl 4-[(3-bromo-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)carbonyl]piperidine-1-carboxylate

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Technology Process of 9H-fluoren-9-ylmethyl 4-[(3-bromo-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)carbonyl]piperidine-1-carboxylate

There total 7 articles about 9H-fluoren-9-ylmethyl 4-[(3-bromo-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)carbonyl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 816464-43-4
9H-fluoren-9-ylmethyl 4-[(3-amino-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)carbonyl]piperidine-1-carboxylate

: 816464-44-5
9H-fluoren-9-ylmethyl 4-[(3-bromo-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)carbonyl]piperidine-1-carboxylate

Guidance literature:: With t-butylnitrite; copper(ll) bromide; In acetonitrile; at 0 ℃; for 4h;

Reference yield:

: 148928-15-8
1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-4-carboxylic acid

: 816464-44-5
9H-fluoren-9-ylmethyl 4-[(3-bromo-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)carbonyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.58 h / 20 - 60 °C

2.1: thionyl chloride / tetrahydrofuran / 0.5 h / 60 °C

3.1: potassium hydroxide; water / diethyl ether

3.2: 2 h / 0 °C

3.3: 20 °C

4.1: potassium carbonate / acetonitrile / 4 h / 50 °C

5.1: t-butylnitrite; copper(ll) bromide / acetonitrile / 4 h / 0 °C

With potassium hydroxide; thionyl chloride; t-butylnitrite; water; sodium hydride; potassium carbonate; copper(ll) bromide; In tetrahydrofuran; diethyl ether; acetonitrile;

Reference yield:

: 433712-58-4
(9H-fluoren-9-yl)methyl 4-(chlorocarbonyl)piperidine-1-carboxylate

: 816464-44-5
9H-fluoren-9-ylmethyl 4-[(3-bromo-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)carbonyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide; water / diethyl ether

1.2: 2 h / 0 °C

1.3: 20 °C

2.1: potassium carbonate / acetonitrile / 4 h / 50 °C

3.1: t-butylnitrite; copper(ll) bromide / acetonitrile / 4 h / 0 °C

With potassium hydroxide; t-butylnitrite; water; potassium carbonate; copper(ll) bromide; In diethyl ether; acetonitrile;