N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-((triisopropylsilyl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

Base Information

Chemical Name:N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-((triisopropylsilyl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
CAS No.:1309592-53-7
Molecular Formula:C₄₇H₅₅N₅O₇Si
Molecular Weight:830.068
Hs Code.:

N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-((triisopropylsilyl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

Synonyms:N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-((triisopropylsilyl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

Suppliers and Price of N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-((triisopropylsilyl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 24 raw suppliers

Chemical Property of N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-((triisopropylsilyl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

Chemical Property:

Purity/Quality:: 99% ,98%,Electron Grade , ^*data from raw suppliers

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Technology Process of N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-((triisopropylsilyl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

There total 1 articles about N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-((triisopropylsilyl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 13154-24-0
triisopropylsilyl chloride

: 129666-75-7,81246-82-4
6-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)adenosine

: 5'-DMTr-2'-TIPS-N-benzoyl-adenosine

: 1309592-53-7
N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-((triisopropylsilyl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

Guidance literature:: 6-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)adenosine; With pyridine; silver nitrate; In tetrahydrofuran; for 0.0833333h;

triisopropylsilyl chloride; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1016/j.tetlet.2011.03.042

Reference yield:

: 1309592-53-7
N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-((triisopropylsilyl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

: N-(9-((2R,3S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-oxo-3-((triisopropylsilyl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

Guidance literature:: With pyridine; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1309592-53-7
N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-((triisopropylsilyl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

: 123-76-2
levulinic acid

: 1309592-54-8
5'-DMTr-2'-TIPS-3'-levulinyl-N-benzoyl-adenosine

Guidance literature:: levulinic acid; With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 0.166667h;

N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-((triisopropylsilyl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.tetlet.2011.03.042