(2S,5R)-4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-N-phenyl-2-morpholinecarboxamide

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Chemical Name:(2S,5R)-4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-N-phenyl-2-morpholinecarboxamide
CAS No.:1227911-08-1
Molecular Formula:C₂₃H₂₄N₈O₂
Molecular Weight:444.496
Hs Code.:

Synonyms:(2S,5R)-4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-N-phenyl-2-morpholinecarboxamide

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Chemical Property of (2S,5R)-4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-N-phenyl-2-morpholinecarboxamide

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Technology Process of (2S,5R)-4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-N-phenyl-2-morpholinecarboxamide

There total 6 articles about (2S,5R)-4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-N-phenyl-2-morpholinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1227911-07-0
(2S,5R)-4-[2-amino-6-(4-cyano-3-fluorophenyl)-4-pyrimidinyl]-5-methyl-N-phenyl-2-morpholinecarboxamide

: 1227911-08-1
(2S,5R)-4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-N-phenyl-2-morpholinecarboxamide

Guidance literature:: With hydrazine hydrate; In ethanol; at 100 ℃; for 24h; Sealed tube;

Reference yield:

: 1227911-03-6
[(2S,5R)-5-methyl-2-morpholinyl]methanol hydrochloride

: 1227911-08-1
(2S,5R)-4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-N-phenyl-2-morpholinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 160 °C / Microwave irradiation

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 100 - 120 °C / Microwave irradiation

3: chromium(VI) oxide; periodic acid / water; acetonitrile / 0 - 15 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 - 20 °C

5: hydrazine hydrate / ethanol / 24 h / 100 °C

With chromium(VI) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; benzotriazol-1-ol; hydrazine hydrate; periodic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetonitrile; 2: Suzuki coupling;
DOI:10.1021/jm101527u

Reference yield:

: 1227911-04-7
[(2S,5R)-4-(2-amino-6-chloro-4-pyrimidinyl)-5-methyl-2-morpholinyl]methanol

: 1227911-08-1
(2S,5R)-4-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-N-phenyl-2-morpholinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 100 - 120 °C / Microwave irradiation

2: chromium(VI) oxide; periodic acid / water; acetonitrile / 0 - 15 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 - 20 °C

4: hydrazine hydrate / ethanol / 24 h / 100 °C

With chromium(VI) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; benzotriazol-1-ol; hydrazine hydrate; periodic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetonitrile; 1: Suzuki coupling;
DOI:10.1021/jm101527u