Technology Process of (2S,5R)-5-methyl-4-(phenylmethyl)-2-morpholinylmethanol
There total 3 articles about (2S,5R)-5-methyl-4-(phenylmethyl)-2-morpholinylmethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-(-)-epichlorohydrin; (2R)-2-[(phenylmethyl)amino]-1-propanol;
With
lithium perchlorate;
In
toluene;
for 48h;
Inert atmosphere;
With
sodium methylate;
In
methanol; toluene;
for 72h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: toluene / Reflux
2.1: sodium tetrahydroborate / ethanol / 0 °C
3.1: lithium perchlorate / toluene / 48 h / 20 °C / Inert atmosphere
3.2: 72 h / 20 °C
With
sodium tetrahydroborate; lithium perchlorate;
In
ethanol; toluene;
DOI:10.1021/jm101527u
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate / ethanol / 0 °C
2.1: lithium perchlorate / toluene / 48 h / 20 °C / Inert atmosphere
2.2: 72 h / 20 °C
With
sodium tetrahydroborate; lithium perchlorate;
In
ethanol; toluene;
DOI:10.1021/jm101527u
