trans-4-[([1-(2,3-dihydro-1-benzofuran-5-yl)ethyl]{4-[2-(2,5-dioxo-pyrrolidin-1-yl)ethoxy]-3-methoxy-benzyl}amino)methyl]cyclohexanecarboxylic acid

Base Information

Chemical Name:trans-4-[([1-(2,3-dihydro-1-benzofuran-5-yl)ethyl]{4-[2-(2,5-dioxo-pyrrolidin-1-yl)ethoxy]-3-methoxy-benzyl}amino)methyl]cyclohexanecarboxylic acid
CAS No.:1443019-04-2
Molecular Formula:C₃₂H₄₀N₂O₇
Molecular Weight:564.679
Hs Code.:

trans-4-[([1-(2,3-dihydro-1-benzofuran-5-yl)ethyl]{4-[2-(2,5-dioxo-pyrrolidin-1-yl)ethoxy]-3-methoxy-benzyl}amino)methyl]cyclohexanecarboxylic acid

Synonyms:trans-4-[([1-(2,3-dihydro-1-benzofuran-5-yl)ethyl]{4-[2-(2,5-dioxo-pyrrolidin-1-yl)ethoxy]-3-methoxy-benzyl}amino)methyl]cyclohexanecarboxylic acid

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Chemical Property of trans-4-[([1-(2,3-dihydro-1-benzofuran-5-yl)ethyl]{4-[2-(2,5-dioxo-pyrrolidin-1-yl)ethoxy]-3-methoxy-benzyl}amino)methyl]cyclohexanecarboxylic acid

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Technology Process of trans-4-[([1-(2,3-dihydro-1-benzofuran-5-yl)ethyl]{4-[2-(2,5-dioxo-pyrrolidin-1-yl)ethoxy]-3-methoxy-benzyl}amino)methyl]cyclohexanecarboxylic acid

There total 12 articles about trans-4-[([1-(2,3-dihydro-1-benzofuran-5-yl)ethyl]{4-[2-(2,5-dioxo-pyrrolidin-1-yl)ethoxy]-3-methoxy-benzyl}amino)methyl]cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₄₂N₂O₇

: 1443019-04-2
trans-4-[([1-(2,3-dihydro-1-benzofuran-5-yl)ethyl]{4-[2-(2,5-dioxo-pyrrolidin-1-yl)ethoxy]-3-methoxy-benzyl}amino)methyl]cyclohexanecarboxylic acid

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 60 ℃; for 3h;
DOI:10.1016/j.bmcl.2016.10.035

Reference yield:

: 1443021-68-8
1-{2-[4-({[1-(2,3-dihydrobenzofuran-5-yl)ethyl]amino}methyl)-2-methoxyphenoxy]ethyl}pyrrolidine-2,5-dione

: 1443019-04-2
trans-4-[([1-(2,3-dihydro-1-benzofuran-5-yl)ethyl]{4-[2-(2,5-dioxo-pyrrolidin-1-yl)ethoxy]-3-methoxy-benzyl}amino)methyl]cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C

2: hydrogenchloride / 1,4-dioxane; water / 3 h / 60 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 1443019-04-2
trans-4-[([1-(2,3-dihydro-1-benzofuran-5-yl)ethyl]{4-[2-(2,5-dioxo-pyrrolidin-1-yl)ethoxy]-3-methoxy-benzyl}amino)methyl]cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 15 h / Reflux

2: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C

3: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C

4: hydrogenchloride / 1,4-dioxane; water / 3 h / 60 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;