1-(3-(2-methoxyethoxy)benzyl)-5-(5-(4-(tetrahydro-2H-pyran-4-yl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one

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Chemical Name:1-(3-(2-methoxyethoxy)benzyl)-5-(5-(4-(tetrahydro-2H-pyran-4-yl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one
CAS No.:1571024-09-3
Molecular Formula:C₂₈H₂₉N₃O₅
Molecular Weight:487.555
Hs Code.:

Synonyms:1-(3-(2-methoxyethoxy)benzyl)-5-(5-(4-(tetrahydro-2H-pyran-4-yl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one

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Chemical Property of 1-(3-(2-methoxyethoxy)benzyl)-5-(5-(4-(tetrahydro-2H-pyran-4-yl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one

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Technology Process of 1-(3-(2-methoxyethoxy)benzyl)-5-(5-(4-(tetrahydro-2H-pyran-4-yl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one

There total 9 articles about 1-(3-(2-methoxyethoxy)benzyl)-5-(5-(4-(tetrahydro-2H-pyran-4-yl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1571032-97-7,1571033-57-2
N'-hydroxy-1-(3-(2-methoxyethoxy)benzyl)-6-oxo-1,6-dihydropyridine-3-carboximidamide

: 1086391-97-0
4-(tetrahydro-2H-pyran-4-yl)benzoic acid

: 1571024-09-3
1-(3-(2-methoxyethoxy)benzyl)-5-(5-(4-(tetrahydro-2H-pyran-4-yl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one

Guidance literature:: 4-(tetrahydro-2H-pyran-4-yl)benzoic acid; With 1,1'-carbonyldiimidazole; In acetonitrile; at 40 ℃; for 1.5h;

N'-hydroxy-1-(3-(2-methoxyethoxy)benzyl)-6-oxo-1,6-dihydropyridine-3-carboximidamide; In acetonitrile; at 40 ℃; for 12h;

In N,N-dimethyl-formamide; at 150 ℃; for 3h;

Reference yield:

: 74597-04-9
m-hydroxybenzyl bromide

: 1571024-09-3
1-(3-(2-methoxyethoxy)benzyl)-5-(5-(4-(tetrahydro-2H-pyran-4-yl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C

1.2: 4 h / 65 °C

2.1: potassium carbonate / acetone / 0.08 h / 20 °C

2.2: 12 h / 65 °C

3.1: hydroxylamine hydrochloride; triethylamine / ethanol / 2 h / 65 °C

4.1: 1,1'-carbonyldiimidazole / acetonitrile / 1.5 h / 40 °C

4.2: 12 h / 40 °C

4.3: 3 h / 150 °C

With hydroxylamine hydrochloride; potassium carbonate; triethylamine; 1,1'-carbonyldiimidazole; In ethanol; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 620-24-6
3-Hydroxybenzyl alcohol

: 1571024-09-3
1-(3-(2-methoxyethoxy)benzyl)-5-(5-(4-(tetrahydro-2H-pyran-4-yl)phenyl)-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1.5 h / 0 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C

2.2: 4 h / 65 °C

3.1: potassium carbonate / acetone / 0.08 h / 20 °C

3.2: 12 h / 65 °C

4.1: hydroxylamine hydrochloride; triethylamine / ethanol / 2 h / 65 °C

5.1: 1,1'-carbonyldiimidazole / acetonitrile / 1.5 h / 40 °C

5.2: 12 h / 40 °C

5.3: 3 h / 150 °C

With carbon tetrabromide; hydroxylamine hydrochloride; potassium carbonate; triethylamine; triphenylphosphine; 1,1'-carbonyldiimidazole; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;