Technology Process of N,N-diethyl-5,6-dihydro-5-benzyl-6-oxo-phenanthridine-2-carboxamide
There total 6 articles about N,N-diethyl-5,6-dihydro-5-benzyl-6-oxo-phenanthridine-2-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydrogencarbonate / dichloromethane; water / 15 h / 0 - 20 °C
2: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
3: palladium diacetate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate / N,N-dimethyl acetamide / 4 h / 130 °C
4: trifluoroacetic acid / 8 h / Reflux
5: caesium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C
With
palladium diacetate; sodium hydride; sodium hydrogencarbonate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate;
In
dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; trifluoroacetic acid;
3: |Heck Reaction;
DOI:10.1016/j.bmc.2014.05.022
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 60 °C
1.2: 20 °C
2.1: sodium hydrogencarbonate / dichloromethane; water / 15 h / 0 - 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
4.1: palladium diacetate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate / N,N-dimethyl acetamide / 4 h / 130 °C
5.1: trifluoroacetic acid / 8 h / Reflux
6.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 90 °C
With
thionyl chloride; palladium diacetate; sodium hydride; sodium hydrogencarbonate; caesium carbonate; N,N-dimethyl-formamide; tricyclohexylphosphine tetrafluoroborate;
In
dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; trifluoroacetic acid;
4.1: |Heck Reaction;
DOI:10.1016/j.bmc.2014.05.022
