Technology Process of N-(3-amino-9H-β-carbolin-8-yl)benzamide
There total 9 articles about N-(3-amino-9H-β-carbolin-8-yl)benzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrazine hydrate;
In
methanol;
for 5h;
Reflux;
Inert atmosphere;
DOI:10.1016/j.bmcl.2012.03.077
- Guidance literature:
-
Multi-step reaction with 11 steps
1: hydrazine hydrate / pentan-1-ol / 7 h / Reflux; Inert atmosphere
2: hydrogenchloride; sodium nitrite / water / 2 h / 0 °C / Inert atmosphere
3: acetic acid / water / 1 h / Reflux; Inert atmosphere
4: chloroform / 0.5 h / 40 °C / Inert atmosphere
5: sodium nitrate; trifluoroacetic acid / 18 h / 0 - 20 °C / Inert atmosphere
6: hydrogenchloride / water / 12 h / Reflux; Inert atmosphere
7: acetic acid / methanol / 4 h / 20 °C / pH 4 / Inert atmosphere
8: sodium cyanoborohydride / methanol / 1 h / 20 °C / Inert atmosphere
9: hydrogenchloride; tin(II) chloride dihdyrate / methanol; water / 48 h / 0 - 20 °C / Inert atmosphere
10: dmap / chloroform / 24 h / 20 °C / Inert atmosphere
11: palladium 10% on activated carbon; hydrazine hydrate / methanol / 5 h / Reflux; Inert atmosphere
With
hydrogenchloride; dmap; sodium nitrate; tin(II) chloride dihdyrate; palladium 10% on activated carbon; sodium cyanoborohydride; hydrazine hydrate; acetic acid; trifluoroacetic acid; sodium nitrite;
In
methanol; pentan-1-ol; chloroform; water;
3: Curtius rearrangement;
DOI:10.1016/j.bmcl.2012.03.077
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium cyanoborohydride / methanol / 1 h / 20 °C / Inert atmosphere
2: hydrogenchloride; tin(II) chloride dihdyrate / methanol; water / 48 h / 0 - 20 °C / Inert atmosphere
3: dmap / chloroform / 24 h / 20 °C / Inert atmosphere
4: palladium 10% on activated carbon; hydrazine hydrate / methanol / 5 h / Reflux; Inert atmosphere
With
hydrogenchloride; dmap; tin(II) chloride dihdyrate; palladium 10% on activated carbon; sodium cyanoborohydride; hydrazine hydrate;
In
methanol; chloroform; water;
DOI:10.1016/j.bmcl.2012.03.077
