methyl 8-(2-(2,5-dimethylphenyl)acetamido)-1,4-dioxaspiro[4.5]decane-8-carboxylate

Base Information

• Chemical Name: methyl 8-(2-(2,5-dimethylphenyl)acetamido)-1,4-dioxaspiro[4.5]decane-8-carboxylate
• CAS No.: 907187-56-8
• Molecular Formula: C₂₀H₂₇NO₅
• Molecular Weight: 361.438
• Mol file: 907187-56-8.mol

Synonyms:methyl 8-(2-(2,5-dimethylphenyl)acetamido)-1,4-dioxaspiro[4.5]decane-8-carboxylate

Chemical Property of methyl 8-(2-(2,5-dimethylphenyl)acetamido)-1,4-dioxaspiro[4.5]decane-8-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 8-(2-(2,5-dimethylphenyl)acetamido)-1,4-dioxaspiro[4.5]decane-8-carboxylate

There total 5 articles about methyl 8-(2-(2,5-dimethylphenyl)acetamido)-1,4-dioxaspiro[4.5]decane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-(2,5-dimethylphenyl)acetyl chloride (55312-97-5) + methyl [1-amino-4,4-ethylenedioxycyclohexyl]carboxylate → methyl 8-(2-(2,5-dimethylphenyl)acetamido)-1,4-dioxaspiro[4.5]decane-8-carboxylate (907187-56-8)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1021/jf3002069

Reference yield: 49.0%

2-(2,5-dimethylphenyl)acetyl chloride (55312-97-5) + 1,4-dioxaspiro[4,5]decan-8-amino-8-carboxylic acid methyl ester hydrochloride → methyl 8-(2-(2,5-dimethylphenyl)acetamido)-1,4-dioxaspiro[4.5]decane-8-carboxylate (907187-56-8)

Guidance literature:

With potassium carbonate; In acetonitrile; at 5 - 20 ℃; for 3.2h;

Reference yield:

8-amino-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid (54621-18-0) → methyl 8-(2-(2,5-dimethylphenyl)acetamido)-1,4-dioxaspiro[4.5]decane-8-carboxylate (907187-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 7 h / 0 °C / Reflux

2: potassium carbonate / acetonitrile / 3 h / 20 °C

With hydrogenchloride; potassium carbonate; In acetonitrile;

DOI:10.1021/jf3002069

upstream raw materials:

cyclohexanedione monoethylene ketal

8-amino-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid

2-(2,5-dimethylphenyl)acetyl chloride

9,12-dioxa-2,4-diazadispiro[4.2.4^Λ{8}.2^Λ{5}]tetradecane-1,3-dione

Downstream raw materials:

C₂₈H₃₁NO₄

C₂₆H₂₇NO₅

C₂₅H₂₄FNO₄

C₂₅H₂₄ClNO₄