1-[(3R,4S)-1-benzyl-4-(3-chloro-4-fluoro-phenyl)-pyrrolidin-3-yl]-ethanone

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Chemical Name:1-[(3R,4S)-1-benzyl-4-(3-chloro-4-fluoro-phenyl)-pyrrolidin-3-yl]-ethanone
CAS No.:1115961-73-3
Molecular Formula:C₁₉H₁₉ClFNO
Molecular Weight:331.817
Hs Code.:

Synonyms:1-[(3R,4S)-1-benzyl-4-(3-chloro-4-fluoro-phenyl)-pyrrolidin-3-yl]-ethanone

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Chemical Property of 1-[(3R,4S)-1-benzyl-4-(3-chloro-4-fluoro-phenyl)-pyrrolidin-3-yl]-ethanone

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Technology Process of 1-[(3R,4S)-1-benzyl-4-(3-chloro-4-fluoro-phenyl)-pyrrolidin-3-yl]-ethanone

There total 1 articles about 1-[(3R,4S)-1-benzyl-4-(3-chloro-4-fluoro-phenyl)-pyrrolidin-3-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1115961-72-2
1-(1-benzyl-2,5-dihydro-1H-pyrrol-3-yl)-ethanone

: 144432-85-9
3-chloro-4-fluorophenylboronic acid

: 1115961-73-3
1-[(3R,4S)-1-benzyl-4-(3-chloro-4-fluoro-phenyl)-pyrrolidin-3-yl]-ethanone

Guidance literature:: With (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; acetylacetonatobis(ethylene)rhodium(I); In methanol; water; at 60 ℃; for 2h;

Reference yield: 22.0%

: 1115961-73-3
1-[(3R,4S)-1-benzyl-4-(3-chloro-4-fluoro-phenyl)-pyrrolidin-3-yl]-ethanone

: 1115961-74-4
(S)-1-[(3R,4S)-1-benzyl-4-(3-chloro-4-fluoro-phenyl)-pyrrolidin-3-yl]-ethanol

: 1115961-75-5
(R)-1-[(3R,4S)-1-benzyl-4-(3-chloro-4-fluoro-phenyl)-pyrrolidin-3-yl]-ethanol

Guidance literature:: 1-[(3R,4S)-1-benzyl-4-(3-chloro-4-fluoro-phenyl)-pyrrolidin-3-yl]-ethanone; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran;