Technology Process of N1,N4,N8-Tris(N-methyl-N-(benzyloxy)malonamoyl)spermidine
There total 8 articles about N1,N4,N8-Tris(N-methyl-N-(benzyloxy)malonamoyl)spermidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap;
In
tetrahydrofuran;
for 16h;
Ambient temperature;
DOI:10.1021/jm00122a013
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 98 percent / K2CO3 / H2O; ethyl acetate / Heating
2: 10.5 g / K2CO3 / acetone / 12 h / Heating
3: 93 percent / 33percent HBr/HOAc / 4 h / Ambient temperature
4: 1.) N,N'-carbonyldiimidazole / 1.) CH2Cl2, room temperature, 2.) CH2Cl2
5: 88 percent / Na2S*9H2O / tetrahydrofuran; H2O / Ambient temperature
6: 61 percent / 1,3-dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0-5 deg C, 3 h, 2.) room temperature, 15 h
7: 63 percent / DMAP / tetrahydrofuran / 16 h / Ambient temperature
With
dmap; sodium sulfide; hydrogen bromide; potassium carbonate; acetic acid; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; water; ethyl acetate; acetone;
DOI:10.1021/jm00122a013
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) N,N'-carbonyldiimidazole / 1.) CH2Cl2, room temperature, 2.) CH2Cl2
2: 88 percent / Na2S*9H2O / tetrahydrofuran; H2O / Ambient temperature
3: 61 percent / 1,3-dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0-5 deg C, 3 h, 2.) room temperature, 15 h
4: 63 percent / DMAP / tetrahydrofuran / 16 h / Ambient temperature
With
dmap; sodium sulfide; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; water;
DOI:10.1021/jm00122a013
