benzyl 2-hydroxy-d-methyl-4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>pyrrole-5-carboxylate

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Chemical Name:benzyl 2-hydroxy-d-methyl-4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>pyrrole-5-carboxylate
CAS No.:143085-35-2
Molecular Formula:C₂₀H₂₃NO₇
Molecular Weight:390.397
Hs Code.:

Synonyms:benzyl 2-hydroxy-d-methyl-4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>pyrrole-5-carboxylate

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Chemical Property of benzyl 2-hydroxy-d-methyl-4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>pyrrole-5-carboxylate

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Technology Process of benzyl 2-hydroxy-d-methyl-4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>pyrrole-5-carboxylate

There total 5 articles about benzyl 2-hydroxy-d-methyl-4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>pyrrole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72423-57-5
5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3methoxycarbonylmethylpyrrole-2-carboxylic acid

: 143085-35-2
benzyl 2-hydroxy-d-methyl-4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>pyrrole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / 1.) NaHCO₃, 2.) I₂, KI / 1.) H₂O, CH₂Cl₂, reflux, 2.) H₂O, reflux, 0.5 h

2: 72 percent / H₂, Et₃N / PtO₂ / methanol / 3 h / Ambient temperature

3: 1.) pocL₃ / 1.) CH₂Cl₂, r. t., 30 min, 2.) overnight

4: 1.) R-alpine borane, 2.) 2-aminoethanol / 1.) THF, r. t., overnight

With B-isopinocampheyl-9-borabicyclo[3.3.1]nonane; hydrogen; iodine; sodium hydrogencarbonate; ethanolamine; triethylamine; potassium iodide; trichlorophosphate; platinum(IV) oxide; In methanol;
DOI:10.1016/S0040-4020(01)81567-2

Reference yield:

: 72423-67-7
benzyl 2-iodo-3<(methoxycarbonyl)methyl>-4-<β-(methoxycarbonyl)ethyl>-5-pyrrolecarboxylate

: 143085-35-2
benzyl 2-hydroxy-d-methyl-4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>pyrrole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / H₂, Et₃N / PtO₂ / methanol / 3 h / Ambient temperature

2: 1.) pocL₃ / 1.) CH₂Cl₂, r. t., 30 min, 2.) overnight

3: 1.) R-alpine borane, 2.) 2-aminoethanol / 1.) THF, r. t., overnight

With B-isopinocampheyl-9-borabicyclo[3.3.1]nonane; hydrogen; ethanolamine; triethylamine; trichlorophosphate; platinum(IV) oxide; In methanol;
DOI:10.1016/S0040-4020(01)81567-2

Reference yield:

: 50622-64-5
benzyl 3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-5-methylpyrrole-2-carboxylate

: 143085-35-2
benzyl 2-hydroxy-d-methyl-4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>pyrrole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) SO₂Cl₂, 2.) H₂O / 1.) CH₂Cl₂, r. t., 2 h, 2.) acetone, reflux, 15 min

2: 80 percent / 1.) NaHCO₃, 2.) I₂, KI / 1.) H₂O, CH₂Cl₂, reflux, 2.) H₂O, reflux, 0.5 h

3: 72 percent / H₂, Et₃N / PtO₂ / methanol / 3 h / Ambient temperature

4: 1.) pocL₃ / 1.) CH₂Cl₂, r. t., 30 min, 2.) overnight

5: 1.) R-alpine borane, 2.) 2-aminoethanol / 1.) THF, r. t., overnight

With sulfuryl dichloride; B-isopinocampheyl-9-borabicyclo[3.3.1]nonane; water; hydrogen; iodine; sodium hydrogencarbonate; ethanolamine; triethylamine; potassium iodide; trichlorophosphate; platinum(IV) oxide; In methanol;
DOI:10.1016/S0040-4020(01)81567-2